Gene editing aims to make precise changes to the target DNA whilst avoiding altering other parts of the DNA. The objective of this is to remove undesirable genetic traits and introduce desirable changes in both plants and animals. For example, it could be used to make crops more drought resistant, prevent or cure inherited genetic…

The immune system plays a key role in tissue regeneration and the various types of immune cells such as macrophages, can help or hinder that repair process. Inflammation is part of the immune response but with aging that immune response becomes deregulated and the inflammation becomes excessive. Excessive levels of inflammation generally speaking inhibit tissue…

Today we have a new study where researchers have created immune cells that ignore the way cancer tries to hide from detection. Hiding in plain sight The Macrophages are one of the types of immune cell and are responsible for dealing with dangerous cells, such as those which have become cancerous. The problem is most…

The evidence that the immune system, and in particular the various types of tissue resident macrophages, play an important role in the regeneration of tissue continues to mount up. The difference in the behaviour of these macrophages varies between species and may significantly contribute to the differences in regenerative capacity observed between slow regenerative species,…

Chronological age is now generally accepted by academics as being a poor means to identify how a person is aging. Far more useful is a person’s biological age in evaluating how fast someone is aging. Biological age is assessed using indicators known as aging biomarkers, and as rejuvenation biotechnology draws ever nearer, there is an…

Fisetin is a naturally occurring plant polyphenol from the flavonoid group, similar to quercetin. It is present in many plants, where it acts as a colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers. It has also been found to be a senolytic compound able…

Recently a journal landed on my desk involving one of my favorite subjects, aging biomarkers. The study authors have been developing a method to allow real-time visualization of senescent cells in living tissues and they have published their findings in the journal of the American chemical society here[1]. Unfortunately, like a lot of science (up…

 Cancer is predominantly a disease of aging caused by genomic instability. Finding effective ways to prevent and treat cancer is therefore of great interest to those working in the field of aging research as well as those working in oncology.  Therapies that target combinations of neoantigens, distinctive markers on the surface of cancer cells that…

Researchers in Cambridge have created a new approach for creating and transplanting artificial bile ducts with the aim of treating liver disease in children and reducing the need for transplants. The research, published in the journal Nature Medicine, shows how the researchers grew 3D cell structures and transplanted them into mice[1]. These structures then developed into…

A new type of cell that can seek and destroy brain cancer and then dispose of themselves has just been successfully tested in mice. The cells are able to home in on brain tumors and reduce them to between 2 to 5% of their original size[1]. This new approach could potentially give doctors a new…

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