History Nicotinic acid is a form of water-soluble vitamin B3. Vitamin B3 and was discovered in 1937 by American biochemist Conrad Elvehjem and as a result cured pellagra, a disease caused by niacin deficiency that causes horrible skin lesions, diarrhea, dementia and even death. This compound is now commonly marketed as niacin and is the…

During my recent journey to Saint-Petersburg to attend the in situ education program of the International Institute on Ageing of the United Nations, Malta (INIA), I asked one of the main speakers, former Head of the UN Programs on Ageing Dr. Alexandre Sidorenko, to find a few minutes to talk about his work. After joining…

Today we offer you an interview with Dr. Marvin Formosa, director of the International Institute on Ageing of the United Nations, Malta (INIA). But first let’s find out, how the issue of population aging was first introduced into the agenda of the United Nations, and why the UN body with focus on aging is located…

The SENS Research Foundation has announced a collaboration with the Buck institute for Research on Aging. The two foundations have collaborated a great deal in the past and the focus of this new research is to be work on cellular senescence in relation to the age-related decline of the immune system. This research was made possible through…

The CRISPR system (Clustered Regularly Interspersed Palindromic Repeats) has exploded onto the biotech sector as a relatively simple, highly efficient and fast method for precisely introducing breaks into genomic loci [1-2]. The realization that it is a prokaryotic acquired immune system, although less mentioned, has been equally paradigm changing [3]. Ironically, it’s the system’s high…

The new research work on senolyic drugs by Baar et al. uses a rationally designed molecule that selectively targets senescent cells in vivo, both in an accelerated aging mouse model, and in normally aged mice as well, with few if any side effects[1]. Senolytics are a new class of potential anti-aging drugs that function by specifically…

Research is increasingly finding a link between the aging process and the lifelong exposure to pathogens. Researchers in this recent study kept mice in a germ free environment and found that the mice had significantly lower levels of inflammation and a marked improvement in their average lifespan[1]. This correlates with another study where mice were…

The biotechnology company PureTech are moving towards human clinical trials with a new therapy that may slow down the aging process and combat age-related disease. The company has licensed two new drug candidates, derivatives of the drug Rapamycin, from pharmaceutical giant Novartis. PureTech have recently announced a joint venture with Novartis called resTORbio and are…

Dr. João Pedro de Magalhães is one of the arguably few people who found their purpose in life at a very young age. When he was still in elementary school, dr. de Magalhães realised that he, like everyone else in the world, suffered from an incurable, progressive disease – aging. Consequently, he decided to become…

DNA is a critical part of the cell, it is the instruction manual for building cells. Whilst DNA is well protected within the cell nucleus damage does occur, therefore DNA repair is absolutely essential for cell function, cell survival and the prevention of cancer. The good news is cells are able to repair damaged DNA…

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