Fisetin is a naturally occurring plant polyphenol from the flavonoid group, similar to quercetin. It is present in many plants, where it acts as a colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers. It has also been found to be a senolytic compound able…

They say you can’t buy happiness, but you can buy wine, and that’s kind of the same thing. But could drinking wine also be adding years to your life? A small compound known as resveratrol might hold the key to this question. History Grapes have been hailed as a miracle cure since 1928, when Johanna…

Meat is rich in creatine, an important energy buffer in muscle cells, and the main constituent of a popular sports supplement used by athletes. But we are now finding out that there’s more to creatine than ‘meats’ the eye. To be clear here, we are not suggesting you wolf down loads of steaks, sausages, bacon….

History Arginine was first isolated from the extract of lupin seedlings by the German chemist Ernst Schultze in 1886. Arginine in nature Arginine is found naturally in a variety of foods, including turkey, pork, chicken, pumpkin seeds, soybeans, peanuts, spirulina, chickpeas, and lentils. Potential health benefits Arginine (also known as L-Arginine) is an important amino…

History Nicotinic acid is a form of water-soluble vitamin B3. Vitamin B3 was discovered in 1937 by American biochemist Conrad Elvehjem, and as a result cured pellagra, a disease caused by niacin deficiency that causes horrible skin lesions, diarrhea, dementia, and even death. This compound is now commonly marketed as niacin and is the third…

Alpha-lipoic acid is a common supplement, but what about its geroprotective properties? We take a look at this supplement in another of our geroprotector articles. History Alpha-lipoic acid (ALA) was first discovered in 1937, when Snell discovered that a type of bacteria relied on potato juice to reproduce[1]. This led to alpha-lipoic acid being known…

We have compiled a list of useful blogs and supplement websites dedicated to healthy life extension. We do not endorse supplement use or any product or supplement vendor and we include such links on the understanding that some members of our community find such topics of interest.               A technical supplement blog focused…

Magnesium is a common element and is found in a variety of foods, but not everyone gets enough of this essential element which is vital for cellular processes. History of Magnesium It was Joseph Black who recognized magnesium as an element back in 1755. However, it was first isolated by Sir Humphry Davy in only 1808….

Today we take a look at one of the more unusual supplements used in traditional medicine for many years. History of honokiol Honokiol is a lignan isolated from the bark, seed cones, and leaves of the trees of various Magnolia species. Honokiol, along with other active molecules in magnolia such as magnolol and obovatol, has…

Glucosamine is one of the most commonly used supplements frequently taken to promote joint health and treat other aches, but there really is more to this dietary supplement than first meets the eye. History of glucosamine Glucosamine was originally discovered during the 1960s in Italy, by pharmacologist Professor Luigi Rovati, the founder of pharmaceutical giant…

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