Osteoarthritis is a common condition that affects your joints and is frequently associated with aging. Today, we look at a new open access paper that discusses the role of aging in the progression of this disease. So what is osteoarthritis? Over time, the surfaces of your joints become worn and damaged, causing them to no…

The next August Journal Club will be on Tuesday August 29th at 13:00 EST/18:00 UK and will be streamed live from Cooper Union to our Facebook page. We have been talking about a number of new studies in past Journal Clubs, so we thought it was time to take a look at the actual delivery…

One of the more important things we can do for longevity is keeping our teeth clean and keeping decay at bay. It might sound strange at first, but it is true. The harm that bacteria causes, especially in the gums, can spread to other tissues and increase inflammation throughout the body. Some studies show a…

There is a growing list of aging biomarkers available to researchers that help them measure how well someone is aging and assess how aging interventions are working in preclinical testing. Some clinical biomarkers, such as DNA methylation and telomere length, are commonly used in labs. Other biomarkers, such as blood pressure, grip strength, heart rate…

As we age, our brains lose their flexibility; this, in turn, affects our ability to learn, to remember things, and to adapt to new situations. The classic example is of older people who are stuck in a rut and unable to change how they think. Some people raise this possibility when any discussion of healthy,…

Cellular senescence is widely considered by academia to be one of the causes of aging and one that leads to a number of age-related diseases. There has been a high level of interest in recent years in cellular senescence and approaches that seek to remove senescent cells as a route to delaying or even preventing…

An interesting new study has demonstrated a method to reprogram specific T cells. Much like researchers have been experimenting recently with macrophages and making them change into an anti-inflammatory rather than a proinflammatory type, the team here has achieved similar results with T cells. As we age, the immune system becomes dysfunctional, either due to…

July 28th saw us run the third Journal Club, where we discussed a recent research publication. Journal Club is a monthly event livestreamed to our Facebook page and runs thanks to the support of our patrons – The Lifespan Heroes. Unfortunately, we had some technical issues with this stream and could not broadcast it live…

In the last year or so, we have seen remarkable progress with a number of interventions that target the aging processes to prevent and treat age-related diseases. Senescent cell clearance has enjoyed lots of media attention and is entering human clinical trials later this year with Unity Biotechnology. We have LysoCLEAR from Ichor Therapeutics moving towards…

A research team led by Dr. Cai at the Albert Einstein college of medicine have shown that stem cells in the hypothalamus influence how fast we age. The new research, shown in mice, may lead to approaches that delay or even prevent age-related diseases[1]. Unfortunately, like 70% of scientific research, this publication is behind a…

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