The new research work on senolyic drugs by Baar et al. uses a rationally designed molecule that selectively targets senescent cells in vivo, both in an accelerated aging mouse model, and in normally aged mice as well, with few if any side effects[1]. Senolytics are a new class of potential anti-aging drugs that function by specifically…

The breaking news today is that yet another research group has entered the field of senescent cell clearance to treat aging. Therapies that remove senescent cells are known as senolytics and they have been a hot topic for the past year or so. Before we talk about the new study let’s take a look at…

Nothing quite compares to a tasty fresh crisp apple, but most people might not know apples contain a very interesting compound that has a number of potential health benefits. History of quercetin Quercetin is a naturally occurring member of the flavonoid family – a large family of water-soluble chemicals, which are not created by the…

Potential Health Benefits From around age forty we start to lose muscle mass due to various aging processes, one of these processes is the accumulation of senescent cells. Senescent cells are simply cells that have become damaged or have reached their maximum number of divisions. Normally these cells are shut down by a kind of…

The clearance of senescent cells has been receiving a great deal of attention in the last year or so, and quite rightly so given the impressive results thus far. As the body ages cells become damaged and cease dividing entering a state known as senescence. Normally these senescent cells destroy themselves through a programmed cell…

The focus of late has been on the removal of senescent cells as a therapy to treat age-related diseases by directly addressing one of the hallmarks of aging – senescent cell accumulation. These senolytic therapies are the first to arrive in the SENS model of directly addressing and repairing the damage that aging does to…

Over the past few weeks CellAge has been producing a number of video shorts to answer questions about their current fundraising campaign on Lifespan.io, so we have compiled them here in a single digest. Their project aims to develop synthetic biology tools for detection and removal of toxic senescent cells that accumulate with time, causing…

< CellAge – Synthetic biology meets senolytics By Steve Hill and Elena Milova  CellAge, together with a leading synthetic biology partner, Synpromics, are poised to develop a technology allowing for the identification and removal of harmful senescent cells. Senescent cells accumulate with age until they reach pathological levels and contribute to age-related diseases and chronic…

  CellAge – the best of AMA By Steve Hill and Elena Milova  CellAge, together with a leading synthetic biology partner, Synpromics, are poised to develop a technology allowing for the identification and removal of harmful senescent cells. Senescent cells accumulate with age until they reach pathological levels and contribute to age-related diseases and chronic…

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