Day 1, Thursday, July 11th

8:00 – 9:00  Registration, Networking

9:00 – 9:10  Welcome talk by LEAF President Keith Comito

9:10 – 9:15  Welcome from Maurice Kanbar Center for Biomedical Engineering Director Oliver Medvedik

9:15 – 9:45
Opening Keynote

Aubrey de Grey – SENS Research Foundation

Estimating the true complexity of comprehensive rejuvenation

09:45 – 11:30
Session 1 – Biomarkers of aging

Morgan Levine – Yale Center for Research on Aging (Y-Age)

DNA methylation landscapes in aging and age-related diseases


Alex Zhavoronkov – Insilico Medicine

Multi-modal biomarkers of aging


Doug Ethell – Leucadia Therapeutics

Predicting Alzheimer’s disease with deep learning


Michael Lustgarten – Tufts University

Role of the gut microbiome on muscle strength in older adults; My n=1 data and the quest for optimal health and lifespan.

11:30 – 11:40  Sponsor presentations
11:40 – Noon Coffee break

Noon – 1:45
Session 2 – Fundamental studies on the root mechanisms of aging, Part 1

George Church – Harvard Medical School

Aging-related gene, cell, & organ therapies


Judith Campisi – The Buck Institute for Research on Aging

Puzzles and promises of cellular senescence


Andrei Gudkov – Roswell Park Comprehensive Cancer Center

‘Retrobiome’ in aging: Intrinsic mechanisms of systemic DNA damage by retroelements and therapeutic approaches to prevent it


Vera Gorbunova – University of Rochester

From long-lived species to anti-aging interventions

1:45 – 2:30  Lunch

2:30 – 3:20
Session 3 – Fundamental studies on the root mechanisms of aging, Part 2

Vadim Gladyshev – Harvard Medical School

From longevity signatures to longevity interventions


Amutha Boominathan – SENS Research Foundation

Remediation of mitochondrial DNA defects via allotopic expression

3:20 – 4:00  Panel discussion: Unlocking funding for basic research on the mechanisms of aging
4:00 – 4:30  Coffee break

4:30 – 6:40
Session 4 – Encouraging progress in aging research

Michael Greve – Forever Healthy Foundation

Accelerating the availability of rejuvenation therapies


João Pedro de Magalhães – University of Liverpool

Prospects, problems and pitfalls in developing aging therapeutics


Huda Suliman – Icaria Life Sciences

Icaria Life Sciences, Inc. – Your partner for aging research


Paul Spiegel – Eclectic Law

California Healthy Aging Initiative: allocating funding for aging research


Kristen Fortney – BioAge

Leveraging AI, genomics, and biobanks to extend human lifespan and healthspan

6:40 – 7:00  Networking

Day 2, Thursday, July 12th

8:00 – 9:00  Registration, Networking
9:00 – 9:10  Welcome talk by Maurice Kanbar Center for Biomedical Engineering Director Oliver Medvedik

9:10 – 9:40
Opening Keynote

Ronald Kohanski – NIA

Concepts and perspectives in geroscience

9:40 – 11:30
Session 5 – Creating interventions against aging, Part 1

María Blasco – CNIO

Telomere-based therapeutic strategies for cancer and age-related diseases


Michael West – AgeX Therapeutics

The reversal of the aging of human cells: strategies for clinical implementation


Greg Fahy – Intervene Immune

Intervene Immune: Reversing human aging right now!


Reason – Repair Biotechnologies

Developing therapies for thymus regeneration and atherosclerosis reversal

11:30 – 11:40  Sponsor presentations
11:40 – Noon  Coffee break

Noon – 1:45
Session 6 – Creating interventions against aging, Part 2

Kelsey Moody – Ichor Therapeutics

Towards enzyme augmentation therapy (EAT) for macular degeneration


Pam Maher – Salk Institute for Biological Studies

Novel anti-aging compounds based on natural products for the treatment of Alzheimer’s disease


John Lewis – Oisin Biotechnologies

Systemic senolysis in naturally aged mice


Jared Fischer – Oregon Health and Science University

Rationally designed FOXO4-p53 interfering peptide selectively kills chemotherapy-induced senescent and dormant cancer cells in vivo

1:45 – 2:30  Lunch

2:30 – 3:50
Session 7 – Creating interventions against aging, Part 3

Kevin Strange – Novo Biosciences

Rethinking regenerative medicine: developing small molecule drugs that unlock our innate regenerative potential


Jay Sarkar – Turn.bio

Epigenetic reprogramming for multifaceted reversal of aging phenotypes


Peter Fedichev – GERO

Hacking aging: a data-driven approach to healthy life extension

3:50 – 4:30  Panel discussion: Unlocking a future without age-related diseases: a forecast
4:30 – 5:00  Coffee break

5:00 – 6:15
Session 8 – Investors’ perspectives on developing a rejuvenation industry

Joe Betts-Lacroix – YCombinator

The law of the instrument


James Peyer – Kronos BioVentures

Addressing the most challenging problems in longevity with a VentureLabs model


Sree Kant – Life Biosciences

Novel investment paradigms in aging research

6:15 – 6:55  Panel discussion: Dialogue between investors and rejuvenation biotech
6:55 – 7:00  Closing remarks by LEAF President Keith Comito
7:00 – 7:30  Networking