Research roundup: The naked (mole rat) truth, and more

What good is a longer life if you have to spend half of it keeping up with the news? Ditch those endlessly scrolling feeds, and instead join us every other week for a concentrated dose of the most exciting developments in the field of geroscience. Here’s the recap: Naked mole rats really do age better,…

Research roundup: Muscles from the lab, and more

We know you want to keep up with the relentless march of progress, but sometimes it’s just too relentless. So why not forget all those endlessly scrolling feeds, and instead join us for a bi-weekly concentrated dose of all the most exciting developments in the field of geroscience? Here’s what’s happened in the last two weeks:…

Will this protein help speed up clinical trials?

Biomarkers are a big deal in the clinical world: if as a doctor you’re able to take one simple measurement that allows you to look into a patient’s future, you’ve potentially elevated your practice of medicine from imprecise art to exact science. The better the biomarkers in your arsenal, the more information you have to…

James Peyer: Navigating the “Biotech Valley of Death”

Ever hear about an exciting discovery in the biomedical world, then later wonder why it seemingly dropped off the face of the Earth? In fact, it’s par for the course for potential therapeutics to fail before they ever get off the ground, guided unwittingly by their enthusiastic champions straight into a boneyard strewn with the…

Research roundup: The microbiome in neurodegenerative disease, and more

It’s looking increasingly likely that our little bacterial buddies have a major influence on neurodegenerative disease, from producing extra amyloid, to regulating inflammation, to generating free radicals. In mouse models of Alzheimer’s disease, a protein complex that forms part of the nervous system’s innate immune system binds to toxic amyloid-beta, promoting the formation of plaques.

The Hallmarks of Aging: Loss of Proteostasis

Part of a series on the Hallmarks of Aging. Proteins don’t do everything in your body, but it’s fair to say they control everything. What they don’t do directly, they catalyze. Proteins handle everything from copying DNA, to stabilizing a neuron’s physical structure, to turning starch into sugar. If something goes wrong in the body,

Merry Media, And A Happy New Year

We want you! Reason over at Fight Aging! lists nine promising approaches to rejuvenation therapy that he’d like to see in the very near future: assessment of senolytics, medical tourism, immune rejuvenation, glucosepane cross-link breaking, amyloid clearance, lysosome cleanup, telomere-centric blockades of cancer, cell therapies, and improved gene therapy. If this describes your work, consider

Research roundup: The importance of energy in Alzheimer’s, and more

Since the world of Alzheimer’s therapeutics hasn’t seen much practical benefit from targeting harmful proteins like amyloid-beta, maybe other approaches like targeting dysfunctional mitochondria are worth exploring in more depth. Apparently, improving mitochondrial function can decrease plaque burden and improve cognition in a mouse model. Why do cancer survivors have shorter lifespans than the rest

Research roundup: Tau tangles guilty by association, and more

It looks like those clumps of tau protein that form inside the neurons of Alzheimer’s brains may actually be protective, and the real damage might instead come from tau oligomers. If you take a major flesh wound to the emergency room for treatment, they probably won’t slather a metformin cream on you… but maybe they…

FOXO vs. a harbinger of neurodegeneration

Long before the usual physiological signs, the withering of neurons and the gradual atrophy of the brain, that tip doctors off to the presence of a neurodegenerative disease, there’s already something different about their patients’ brain cells. Action potentials flash across a long, thin arm protruding from the cell body in a healthy neuron, and…

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