How many mutations before stem cells go kaput?

Imagine that today is your first day at a brand new job, and your new boss slaps an enormous booklet on your desk, then walks off without a word. The front of the booklet reads “HOW TO DO YOUR JOB”, and underneath in smaller print is the word accountant, and underneath that is the number…

Space aging

People have been talking about terraforming and colonizing Mars since the beginning of space travel, and in the past few years that ambition seems to have gone mainstream. But if we want to conquer the “final frontier” of space, we must first confront that other final frontier. Because, as it turns out, the problem with…

Research roundup: Muscles from the lab, and more

We know you want to keep up with the relentless march of progress, but sometimes it’s just too relentless. So why not forget all those endlessly scrolling feeds, and instead join us for a bi-weekly concentrated dose of all the most exciting developments in the field of geroscience? Here’s what’s happened in the last two weeks:…

Oxidative stress response: One of the many jobs of tumor-suppressor p53

At its most dramatic, oxidative stress can rend DNA in two and predispose cells to mutations that ultimately result in cancer. But the less bombastic effects of reactive oxygen molecules are no less damaging, as they likely play a central role in the world’s number one killer, vascular disease, causing stroke and heart attack among

Research roundup: The importance of energy in Alzheimer’s, and more

Since the world of Alzheimer’s therapeutics hasn’t seen much practical benefit from targeting harmful proteins like amyloid-beta, maybe other approaches like targeting dysfunctional mitochondria are worth exploring in more depth. Apparently, improving mitochondrial function can decrease plaque burden and improve cognition in a mouse model. Why do cancer survivors have shorter lifespans than the rest

The Hallmarks of Aging: Telomere Attrition

Part of the Hallmarks of Aging series. What–and why–are telomeres? The chromosomes that store your genetic information are capped at each end by a telomere–a specific DNA sequence, repeated thousands of times. This sequence serves two purposes: it protects the coding regions of the chromosomes from damage, and it provides a “clock” that measures the…

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