Sebastian Aguiar: “The Geroscience Revolution.”

Sebastian Aguiar, geroscientist and Venture Fellow at Apollo Ventures, delivers the Lord Florey Lecture at Lincoln College, Oxford in November 2018. He was a Clarendon Scholar at Lincoln College, Oxford for his DPhil (PhD) on the biochemistry of aging. Aguiar presents topics such as the Silver Tsunami, promising industry developments, and exciting examples of healthspan…

The chaotic inner life of cancer

(Continued from part I) Most people who’ve meet cancer on the battlefield of treatment, doctors or patients, come away with the impression of a robust and formidable foe that can only be defeated with the most terrible weapons. But this impression is somewhat misleading. The cancers that come to our attention are selected for being…

Glucosamine: The new metformin? | Interview with Dr. Michael Ristow (part ii)

Last week when we heard from Dr. Ristow, he turned the outdated notion of the “free radical theory of aging” on its head, and demonstrated that antioxidants like vitamin A and vitamin C aren’t all they’re cracked up to be. But if those supplements can’t help us, what can? Perhaps, says Ristow, the answer can…

James Peyer: Why primary indications matter

“Aging” isn’t a disease as recognized by the FDA–not yet anyway. But then how will the companies trialing anti-aging drugs ever get regulatory approval? It’s simple: just choose a “primary indication” to test your drug with. Of course, that choice itself is rather difficult when you’re considering a geroprotector. Here’s how investors think about it…

Research roundup: Tau tangles guilty by association, and more

It looks like those clumps of tau protein that form inside the neurons of Alzheimer’s brains may actually be protective, and the real damage might instead come from tau oligomers. If you take a major flesh wound to the emergency room for treatment, they probably won’t slather a metformin cream on you… but maybe they…

James Peyer: “The 21st century will be defined by our struggle against the diseases of aging.”

“At what age would you like to get Alzheimer’s?” This was the question posed by venture capitalist, former stem cell biologist and Geroscience co-founder James Peyer at TEDxStuttgart last week. Peyer became a devotee and champion of the anti-aging movement early in his life, and over his career he’s watched the field mature from a collection…

A bountiful harvest of research

Keeping one eye on your calories, and the other on that delicious-looking pumpkin pie? Don’t worry–your Thanksgiving sins probably won’t hurt your longevity as long as you’re fasting sometimes. You can thank your gut bacteria. What do insulin resistance and 17th century Prague have in common? The first rare variant that dramatically increases human lifespan…

Metformin as Geroprotector

The diabetes drug Metformin is handled as new anti-aging compound. But which studies actually promoted the longevity effects of Metformin? We provide an up-to-date table with the newest studies released on Metformin supplementation: Species Aver. life span change [%] Max. life span change [%] Start of treatment Dosage Gender Significance? Reference M. musculus 6 n.m….

Better together? Testing the first combination therapies for longevity

The normal mode of drug discovery is a pretty singular affair: one compound, one disease. This is enough for many traditional diseases, but when you’re facing a complex phenomenon built on innumerable pathways like aging, where existing treatments only scratch the surface, you need to get a little more creative. complex phenomenon built on innumerable…

In the media: Mouse mugshots, metabolic mayhem and metformin

Is a picture worth a thousand biomarkers? MouseAGE, the AI that wants to eyeball the age of rodents, thinks so. thinks so Dr. Craig Thomspon talks cancer metabolism, and fills us in on how certain nutrients may explain the connection between cancer and obesity. “The TAME Trial would cost 96% less than the cost to…

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