Fight Aging!

With the development of rejuvenation therapies underway, and accelerating, somewhere ahead lies a dividing line. Some people will be the last to age to death, too comprehensively damaged for the technologies of the time to recover. Everyone else will live indefinitely in youth and health, protected from aging by periodic repair of the underlying cell…

Fight Aging!

Every new class of rejuvenation therapy, and there will be many of them in the decades ahead, will follow a cycle consisting of a few years of rapidly growing hype, followed by a sharp crash of disappointment, and then, ultimately, long years of slow and steady success. People attach great hopes to the early stages…

For Senolytics Companies, an Effective Piperlongumine would be a Greater Competitive Threat than Dasatinib

Senolytic treatments selectively destroy senescent cells, and several different approaches have been shown to produce some degree of rejuvenation in mice: reversal of measures of aging; reversal of the progression of specific age-related conditions; extension of life span. Most of these initial senolytics are repurposed pharmaceuticals drawn from cancer research databases, with the exceptions being…

Fight Aging!

The average cost of delivering a new therapy from laboratory to clinic is increasing at a fast pace, more than doubling since the turn of the century according to some studies, to stand at $2.5 billion or more. This is not driven by the work of research and development becoming more expensive: if anything, the…

Fight Aging!

Whenever I am told by ethicists that enabling people to live longer is a threat to society, a complex development that must be held back and studied so as to understand how best to allow it to progress, if at all, I have the feeling that I’m being held up for money. Ethics is, I…

Fight Aging!

The International Longevity Center in the UK turns out interesting white papers every so often. Note that the organization is funded by a number of pensions and insurance companies, sizable business concerns whose long term success depends on (a) correctly predicting the future of human aging, and, (b) preventing the short term incentives of politicians…

Fight Aging!

As progress towards actual, real, working rejuvenation therapies becomes ever harder to ignore, even for those without any great familiarity with the sciences, the positions espoused by those opposed to longevity is shifting. It is apparently easy to be opposed to, outraged with, up in arms about the prospect of longer human lives when longer…

Fight Aging!

The two strongest urges are firstly to seek pleasure, in all its myriad forms, and secondly to evade suffering, in all its myriad forms. The primordial glass half full and glass half empty of the human condition. These are the two sides of the hedonistic imperative, and are perhaps the most important motivations guiding the…

Fight Aging!

Our present age of technology and accelerating progress is the first of its kind for our species. It commenced a few short centuries ago with subtle changes in wealth, agriculture, and life expectancy that compounded to form the foundations for the Industrial Revolution. It was a dramatic break with millennia in which stasis or the…

Fight Aging!

I will be 85 somewhere in the mid 2050s. It seems like a mirage, an impossible thing, but the future eventually arrives regardless of whatever you or I might think about it. We all have a vision of what it is to be 85 today, informed by our interactions with elder family members, if nothing…

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