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Cofilin May Link Amyloid-β Aggregation and Tau Aggregation in Alzheimer's Disease

The early stage of Alzheimer’s disease is characterized by the slowly increasing aggregation of amyloid-β into solid deposits, something that may occur due to failing clearance of metabolic waste from the brain via drainage paths for cerebrospinal fluid. The complex biochemistry surrounding amyloid-β is damaging to the operation of brain cells, but not damaging enough…

Fight Aging!

Walking pace, like grip strength, is one of the simple measures used by physicians to assess the progression of frailty in old age. Researchers here report on epidemiological data that shows an association between life expectancy and walking pace, in that older individuals who walk more slowly tend to have a shorter life expectancy. This…

Fight Aging!

Promises to pay at a future date are a dangerous tool in the hands of politicians and state employees, those who suffer little to no personal consequences when past promises are revealed to be based on faulty assumptions and thin air. Either someone ends up paying, usually the taxpayers, or the promises are broken. Pensions…

Studying the function of liver cancer genes in mini-organs

VIDEO: Human liver organoids after introduction of BAP1 mutation: a dramatic change of morphology (solid mass of cells instead of large lumen with single layer of cells around) and behaviour (more… view more  view more  Researchers from the Hubrecht Institute and Radboud University have developed a human model in which they use organoids, or mini organs,…

Children's Tumor Foundation launches NF2 accelerator to combat rare genetic disorder

On the occasion of World NF2 Awareness Day, the Children’s Tumor Foundation has announced the establishment of a significant research initiative dedicated to finding effective treatments for NF2, along with a substantial investment of $2.3 million in this bold new effort. Called the ‘NF2 Accelerator Initiative’, this three-year undertaking will be dedicated to bringing active…

Do physicians properly advise women with dense breasts on cancer risk?

IMAGE: Journal of Women’s Health, the Official Journal of the Academy of Women’s Health, is published 12 years per year in print and online. For more information, visit www.liebertpub.com/jwh…. view more  Credit: ©2012, Mary Ann Liebert, Inc., publishers New Rochelle, NY, May 15, 2019–A new study has shown that more than half of physicians – primary…

Eureka Alert

IMAGE: An ambitious research effort seeks to better treat disease by understanding how cells communicate. The project brings together scientists from many disciplines at the University of Virginia School of Medicine. view more  view more  A groundbreaking research collaboration at the University of Virginia School of Medicine that is shedding light on everything from cancer to…

Fight Aging!

With the development of rejuvenation therapies underway, and accelerating, somewhere ahead lies a dividing line. Some people will be the last to age to death, too comprehensively damaged for the technologies of the time to recover. Everyone else will live indefinitely in youth and health, protected from aging by periodic repair of the underlying cell…

Fight Aging!

Here, one of the leading researchers working on the biochemistry of senescent cells – and their relevance to aging – considers the state of development of senolytic therapies. These are treatments, largely small molecule drugs at this stage, but also including suicide gene therapies, immunotherapies, and more, that are capable of selectively destroying some fraction…

Fight Aging!

The authors of the open access paper here have an intriguing view of the way in which regenerative processes run awry with age, and thus contribute to the aging process. As is the case for many single mechanism proposals regarding aging, I think that the viewpoint is useful, but the mechanism in question is probably…

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