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Fight Aging!

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn’t work when it comes to…

Reviewing the Reserve Supply of Immature Neurons in the Adult Brain

To what degree can the adult brain restructure and regenerate itself? In one sense the components of the central nervous system, brain included, are clearly among the least regenerative of tissues in mammalian species. In another sense the brain is capable of significant compensatory change following damage. Further, the normal operation of the brain over…

Mitochondrial DNA Damage in Age-Related Macular Degeneration

One of the early features of age-related macular degeneration, in which the retina degenerates, causing progressive blindness, is a rising level of oxidative stress in the retinal pigment epithelium. Researchers here consider a role for mitochondrial DNA damage in the generation of this oxidative damage. Mitochondria are the power plants of the cell, descendants of…

How Might Nutrient Rich Diets Turn Our Gut Bacteria Against Us?

Nutrient rich diets are harmful, even if only considering the accumulation of visceral fat tissue that results from eating more calories than are strictly necessary for sustained periods of time. Visceral fat tissue produces chronic inflammation, and that in turn accelerates progression of all of the common age-related conditions. High nutrient diets also have an…

Eureka Alert

University of Virginia Health System is joining a coalition of healthcare organizations to improve vaccination rates in western Virginia for human papillomavirus (HPV), a leading cause of cancer. Virginia Center for Health Innovation is partnering with 40 pediatric and family medicine sites from UVA, Ballad Health and Carilion Clinic to boost HPV vaccinations with the…

Cancer cells are quick-change artists adapting to their environment

IMAGE: Microscopy image of glioblastoma stem cells growing in different microenvironments. view more  view more  Until now, researchers have assumed that the growth of solid tumors originates from cancer stem cells characterized by specific surface markers, which develop in a fixed, hierarchical order. Accordingly, such cancer stem cells are responsible for tumor progression and produce specific…

CNIO participates in a study identifying a novel oncogene for most common types of blood cancer

Miguel Gallardo, researcher and coordinator of the H12O-CNIO Haematological Malignancies Clinical Research Unit headed by Joaquín Martínez at the Spanish National Cancer Research Centre (CNIO), has participated in a study that revealed that hnRNP K overexpression may cause B-cell lymphomas, the most common types of blood cancer. The finding that this tumour suppressor gene may…

PSA, a prostate cancer marker, activates vascular and lymphangiogenic growth factors

Together with its partners, a research group led by Docent Michael Jeltsch at the University of Helsinki, Finland, has discovered new mechanisms which activate the vascular endothelial and lymphangiogenic growth factors VEGF-C and VEGF-D. These growth factors play a central role not only in fetal development but in the spread of cancer and the formation…

Cofilin May Link Amyloid-β Aggregation and Tau Aggregation in Alzheimer's Disease

The early stage of Alzheimer’s disease is characterized by the slowly increasing aggregation of amyloid-β into solid deposits, something that may occur due to failing clearance of metabolic waste from the brain via drainage paths for cerebrospinal fluid. The complex biochemistry surrounding amyloid-β is damaging to the operation of brain cells, but not damaging enough…

Fight Aging!

Walking pace, like grip strength, is one of the simple measures used by physicians to assess the progression of frailty in old age. Researchers here report on epidemiological data that shows an association between life expectancy and walking pace, in that older individuals who walk more slowly tend to have a shorter life expectancy. This…

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