AMP addresses clinical relevance of DNA variants in chronic myeloid neoplasms

ROCKVILLE, Md. — Aug. 21, 2018 — The Association for Molecular Pathology (AMP), the premier global molecular diagnostics professional society, today published consensus, evidence-based recommendations to aid clinical laboratory professionals with the management of most Chronic Myeloid Neoplasms (CMNs) and development of high-throughput pan-myeloid sequencing testing panels. The report, “Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms (CMNs): A Report of the Association for Molecular Pathology,” was released online ahead of publication in The Journal of Molecular Diagnostics.

CMNs are a complex group of hematopoietic disorders, encompassing myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPNs), and the overlap entities (MDS/MPNs), that causes a person’s bone marrow to make too many, or too few, red blood cells, white blood cells or platelets. The increasing availability of targeted high-throughput next-generation sequencing (NGS) panels has enabled scientists to explore the genetic heterogeneity and clinical relevance of the small DNA variants in CMNs. However, the biological complexity and multiple forms of CMNs has led to variability in the genes included on the available panels that are used to make an accurate diagnosis, provide reliable prognostic information and select an appropriate therapy based on DNA variant profiles present at various time points. The AMP CMN


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