Cellular Damage Drives the Aging of the Kidney

The SENS view of aging is a synthesis of decades of evidence produced by the research community. It is that aging is caused at root by an accumulation of molecular damage in and around cells, damage that occurs as the result of the normal operation of cellular metabolism. The logical approach to aging is therefore to repair this damage, but, sad to say, only a small fraction of the research community pursues work of this nature.

SENS view of agingaccumulation of molecular damagecellular metabolismrepair this damage

Why is this case? Perhaps because the dominant paradigm of investigative research involves picking one age-related disease and then working backwards from the disease state, trying to uncover contributing factors that occur in the final stages of the progression of disease. The first opportunities to produce therapies as a result of increased understanding therefore involve changes in cells and tissue that are far downstream of the root causes of aging, have limited relevance to aging beyond the specific disease, and offer only limited potential benefits. It is not the right path forward if we want to see meaningful progress in our lifetimes.

Autophagy is a process of destruction and processing of damaged cell components by the

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