Aging is a global phenomenon throughout the body, a cascade of increasing complexity that starts with comparatively simple causes. Each of these distinct causes contributes to many age-related conditions, and all interact with one another. So on the one hand it is easy to find correlations between different aspects of aging – it would be surprising if that wasn’t the case. On the other hand, different aspects of aging in different organs will turn out to share the same subset of important root causes, so it should be also possible to identify correlations that stand apart from the rest of the progression of aging.
Intrinsic skin aging and cardiovascular disease are two such linked manifestations of aging. Both are driven by loss of flexibility of tissues. Skin and blood vessel walls suffer issues due to the very similar accumulation of cross-links in the extracellular matrix and the presence of senescence cells and their inflammatory signaling. In skin, the loss of elasticity leads to wrinkles as its most evident manifestation. In the cardiovascular system, the consequences are more severe: failure of feedback mechanisms controlling blood pressure; remodeling of the heart and blood vessels; pressure damage to sensitive tissues; and ultimately