The short commentary here reports on an investigation of the benefits of exercise as a compensatory therapy to reduce the impact of Parkinson’s disease. Physical activity and physical fitness produce benefits that are on a par with many pharmaceutical and other therapies when it comes to the progression of age-related diseases. This is as much a judgement on the feeble, marginal nature of so much of present day medicine as it is a statement on the merits of exercise. These therapies are marginal because they fail to tackle the root causes of aging. They attempt to influence the downstream, failing state of cellular activity and metabolism. It is akin to changing the oil in an old engine and pressing the accelerator harder rather than replacing the problem parts.
Physical exercise has repeatedly been demonstrated to alleviate comorbidities associated with aging, and to contribute to reducing an individual’s risk of developing neurodegenerative conditions such as Parkinson’s disease (PD) or Alzheimer’s disease (AD). Evidence has accumulated to suggest that exercise can ameliorate many of the symptoms of PD, not only the motor dysfunction, but also some of the non-motor symptoms (NMS), such as cognitive impairment and depression.