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Clearance of Senescent Cells Reverses Cardiac Fibrosis and Hypertrophy in Mice
Cells become senescent in response to a toxic environment, or during regeneration, or when damaged in ways that may increase cancer risk, but the vast majority are created when cells reach the end of their replicative life span, the Hayflick limit. Senescence is irreversible, and a senescent cell is blocked from