IMAGE: A research team from the Cancer Science Institute of Singapore at the National University of Singapore, led by Professor Yoshiaki Ito (left), and involving Senior Research Scientist Dr Vaidehi Krishnan… view more
Credit: National University of Singapore
A study by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed that RUNX proteins are integral to efficient DNA repair via the Fanconi Anemia (FA) pathway.
Led by Professor Yoshiaki Ito, Senior Principal Investigator at CSI Singapore, and involving Senior Research Scientist Dr Vaidehi Krishnan and former CSI Singapore researcher Dr Lavina Tay, the team undertook a thorough molecular characterisation of RUNX proteins in the FA pathway that showed that the proteins had substantial physical association with DNA repair complexes and co-regulated the recruitment of DNA repair protein FANCD2 to sites of DNA damage.
Fanconi Anemia pathway involved in DNA repair
“Humans are constantly exposed to mutagenic DNA damaging lesions called DNA interstrand crosslinks (ICLs) which can be induced by environmental sources such as formaldehyde, and chemotherapeutics such as cisplatin. Left unrepaired, ICLs could drastically increase predisposition to cancer,” explained Prof Ito, who is a widely recognised scientist for his research
Article originally posted at