Recipe for the perfect balance of breaks and repairs in our genome could help fight cancer and brain ageing
New discovery gives insight into chemotherapy resistant cancers such as rhabdosarcoma – the most common soft tissue cancer in children Findings could have significant implications in brain ageing which has an effect on memory and cognitive function
Scientists at the University of Sheffield have discovered what keeps the perfect balance of breaks and repairs in our DNA – something which could help improve the success of chemotherapy and combat neurodegeneration associated with ageing.
Our genome, where precious genetic information is stored, is challenged with thousands of breaks every day.
Cells possess an army of proteins that search for, detect and fix these breaks to maintain genome integrity, but little is known about how the cell fine-tunes the level of response in these repair factories to suit each and every repair event.
The level of proteins in our cells is controlled by synthesis and degradation. Cells get rid of proteins when not needed by attaching a small peptide called ubiquitin.
The new study, led by Dr Sherif El-Khamisy at the University of Sheffield’s Department of Molecular Biology and Biotechnology, has revealed
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