Scaffolds Protect Transplanted Stem Cells to Increase Therapeutic Benefit

One of the major areas of focus in regenerative research is finding ways to enhance the ability of transplanted cells to integrate with tissue, survive, and induce healing and growth. In early, first generation stem cell therapies, near all cells die quite quickly. The span of benefits that result is a reaction of native cells to the molecular signals briefly generated by the transplanted cells. The anti-inflammatory effects of mesenchymal stem cell therapies as presently practiced is a good example.

stem cell therapiesmesenchymal stem cell therapies

One way to improve cell survival is to build an artificial environment that to some degree mimics the extracellular matrix. Given that starting point, however, one can start adding additional features, such as molecular signals that enhance cell resilience, or structures that isolate cells for a time from hostile surroundings. Scaffolding materials are evolving to primarily provide protection for transplanted cells, rather than just a familiar three-dimensional structure.

extracellular matrix

A car accident leaves an aging patient with severe muscle injuries that won’t heal. Treatment with muscle stem cells from a donor might restore damaged tissue, but doctors are unable to deliver them effectively. A new method may help change this. Researchers engineered a molecular matrix, a

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