Sub-fertility in men treated with ICSI associated with an increased risk of prostate cancer

Barcelona, 3 July 2018: Subfertile men who have received fertility treatment with the microinjection technique of ICSI (intracytoplasmic sperm injection) have been found at a significantly greater risk of prostrate cancer, according to an analysis of three comprehensive nationwide registries in Sweden.

“The results show immense risk for early-onset prostate cancer,” say the authors, who describe this form of cancer as “generally considered more aggressive”.

However, the investigators stress that this risk seems related to the male patients’ sub-fertility and not to the ICSI procedure itself, which in this study is recognised as an indication for treatment of male factor infertility.

Results of this registry study, which sourced data from the Swedish Medical Birth Register, the Swedish Cancer Registry and the Swedish Quality Register for Assisted Reproduction to identify all fathers and their first child born in Sweden between 1994 and 2014, are presented today by PhD student Yahia Al-Jebari from Lund University in Sweden. The study itself compared the risk of being diagnosed with prostate cancer in the ICSI fathers with those who became fathers by natural conception (controls) and by routine IVF. From the overall total of almost 1.2 million fathers, 3211 prostate cancer cases were identified


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