The State of Evidence for a Novel TP53-DHEAS Anti-Cancer Mechanism in Primates

Are there any comparatively simple ways in which natural cancer suppression mechanisms can be greatly enhanced? This is an interesting question to consider. The current repertoire of the cancer research and medical communities include what are arguably a few examples of an enhanced natural suppression mechanism, such as the various ways to drive more cancerous cells into a state of senescence than would normally make that transition. The study of the comparative biology of aging has uncovered a variety of suppression mechanisms in naked mole rats and elephants that might lead to human therapies, but I suspect that “simple” will not describe the programs needed to make any of those therapies a reality. More practical are means to enhance the immune system’s capacity to attack cancer, spurring greater creation or greater replication of immune cells; examples include present IL-7 recombinant protein therapies, or potential future FOXN1 gene therapies.

senescencecomparative biology of agingnaked mole ratselephantsimmune system’s capacity to attack cancerIL-7 recombinant protein therapiesFOXN1 gene therapies

The author of the open access paper below hypothesizes the existence of a cancer kill switch that has been overlooked largely because it exists in primates but not mice. If he is correct, then this would seem to

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