Eureka Alert

IMAGE: Solving Kids’ Cancer US/UK, Joining Against Cancer in Kids and Band of Parents are four charities that funded this exciting clinical trial for children with neuroblastoma. view more 

Credit: Solving Kids’ Cancer

June 11, 2018 – NEW YORK – Band of Parents, Joining Against Cancer in Kids (J-A-C-K), Solving Kids’ Cancer Europe, and Solving Kids’ Cancer U.S., have partnered to advance new treatment options for children with neuroblastoma with the launch of a transatlantic Phase 1 clinical trial that is open for enrollment in the U.K. and will open soon in the US and Germany. The project is led by Dr. Juliet Gray at Southampton University Hospital and includes researchers at Great Ormond Street (UK), Griefswald University Hospital (Germany), and University of Wisconsin/American Family Children’s Hospital (US).

The MiNivAN study combines 131-I mIBG targeted radiation therapy with two different antibodies, Nivolumab and Dinutuximab beta. Dinituximab beta, an anti-GD2 antibody, has been widely used in neuroblastoma and targets the cancer cells, allowing them to be seen and killed by one’s own the immune system. In contrast, Nivolumab targets the immune system rather than the tumor itself, boosting the body’s immune response to the cancer. The study hopes to prove


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