The February journal club will focus on the recent paper “Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances”. Hosted by Dr. Oliver Medvedik, we will be joined by study authors, Dr. Peter Joshi and Paul Timmers both from the University of Edinburgh, UK who will guide us through this…
Researchers at the Salk Institute have moved a step closer to a possible therapy for Hutchinson-Gilford progeria syndrome, a rare genetic disorder that is often described as accelerated aging, as people with it appear to age far faster than normal. Using a new CRISPR/Cas9 gene therapy in a mouse model, they were able to slow…
In a new study [1], researchers have identified the reason why cells become defective when they grow too large and why protein creation fails when cells grow larger than their original healthy size, as is typically seen in aged and senescent cells. They demonstrate that in enlarged yeast and human cells, RNA and protein biosynthesis…
Researchers at the Harvard T.H. Chan School of Public Health have discovered a new aging clock that can accurately determine both chronological and biological age in a wide variety of species. Aging and the nucleolus There are two kinds of age: chronological age, which is strictly the number of years that something has lived, and…
A research team led by Professor Johann de Bono at the Institute of Cancer Research, London has successfully tested a new drug that has infiltrated different forms of cancer in an ongoing human trial [1]. The drug is called tisotumab vedotin (TV) and works like a ‘Trojan Horse’ by hiding a cancer-killing payload inside an…
A collection of sixteen senior scientists have created an academy in Boston in order to showcase the important work currently being conducted on human aging and how researchers are developing ways to slow or even reverse it. The Academy for Health and Lifespan Research is a nonprofit organization that will be organizing a series of…
We recently visited the Longevity Leaders Conference in London and had the opportunity to speak with Kelsey Moody, the CEO of Ichor Therapeutics, a company focused on targeting age-related diseases by targeting the aging processes themselves. We previously interviewed him back in 2017, so it was the ideal time to catch up on what had…
Researchers at Newcastle University have shown that clearing out senescent cardiac muscle cells from the hearts of aged mice restores heart health. It seems that not a month goes by without a new study showing that senolytics, drugs that remove aged and damaged cells from the body, improve organ or tissue function by reversing some…
In aging research, there has long been a need for better biomarkers that can detect and confirm the presence of senescent cells. This has become particularly urgent in recent years due to the meteoric rise of the senescent cell-clearing therapies known as senolytics. Traditional ways of measuring senescent cell populations are problematic and have multiple…
The MouseAge project was launched last year after successful fundraising on Lifespan.io. It aimed to develop the first photographic biomarker of aging in mice to help researchers assess potential anti-aging therapies, reduce animal testing, and speed up the pace of aging research. The major advantage of this approach as opposed to other biomarkers of aging,…