Sirtuins have long been implicated in playing a role in the longevity of various species, including our own, and researchers at the University of Rochester have now discovered more supporting evidence that they do. What are sirtuins? Sirtuins are a family of proteins that facilitate cellular function and have long been known to play a…
Mesenchymal stem cells (MSCs) have been a topic of great interest in the last decade or so due to their ability to improve tissue regeneration merely by their presence and the secreted signals they give out. Adult MSCs have traditionally been used for regenerative medicine with hit-and-miss results, depending on the quality and age of…
Earlier this year, we launched a new webinar series where our monthly patrons, the Lifespan Heroes, are given the opportunity to join live discussion panels with the researchers who are working on solving aging. Our April 8th, 2019 episode saw Dr. Mike Lustgarten, Dr. Amy Proal, and Dr. Cosmo Mielke join hosts Dr. Oliver Medvedik…
On July 11-12, we will be hosting our second annual Ending Age-Released Diseases conference. This conference focuses on the progress of aging research along with the business and investment side of rejuvenation biotechnology. Aging research is on the cusp of some major breakthroughs in the battle against age-related diseases, and we invite you to join…
The results of a clinical trial using bone marrow-derived mesenchymal stromal cells (MSCs) to treat late-stage knee osteoarthritis were published recently, and they came back positive. The trial included both phase 1 and 2 and was designed to determine the safety and efficacy of MSC stem cell therapy. A battery of tests During the trial,…
Professor Jerry Shay of the Shay/Wright lab is perhaps most well-known for his research on telomeres and telomerase and their relation to cancer and aging. He has been instrumental in the development of telomerase inhibitors, which turn off the expression of telomerase in cancer cells; this expression is one way in which cancer cells become…
A small update from the MMTP project team following meeting the lead investigator Dr. Alexandra Stolzing in Berlin recently. Hi everyone, it has been a while and as we have recently spoken to Dr. Alexandra Stolzing at the Undoing Aging conference in Berlin about the MMTP we wanted to give a small update. Dr. Stolzing…
At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages of aging and may one day lead to a future without the diseases of aging. We were glad to have the opportunity to conduct a…
A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit, they were able to reverse cognitive decline and rejuvenate aged mouse brains. Searching for the cause of cognitive decline Microglia are immune cells that reside…
In a new study, researchers show that the presence of senescent cells is an important contributor to aging of the cardiovascular system, particularly the heart [1]. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do not divide or support the tissues of…