We have talked about the potential of partial cellular reprogramming in previous articles, and today, we want to draw attention to a new paper that promises to further refine reversal of epigenetic aging in cells. As we age, our cells experience alterations to their epigenetic markers, and this changes gene expression, which is proposed to…

As mentioned in some recent articles, we are increasing our efforts to reward our loyal and invaluable monthly patrons that support us as Lifespan Heroes. We previously mentioned a brand-new, exclusive webinar series for Lifespan Heroes, and we want to take this opportunity to also announce another brand-new initiative that will commence in April. Introducing…

Last year, resTORbio announced the positive results of its phase 2b human trial, which targeted the aging immune system with an immune system-boosting drug. Now, the company has announced the news that its therapy is moving to a phase 3 study later this year after successful negotiation with the FDA. Targeting the mTOR pathway of…

The skin is our first line of defense against invading pathogens, and scientists at UC San Francisco and the San Francisco Veterans Administration (VA) Health Care System believe that it may be a cause of inflammaging, the age-related chronic inflammation that encourages a number of age-related diseases to develop. As we age, we generally experience…

A new clock that analyzes the age of the immune system may be the next big thing in aging biomarkers. Measuring the age of your immune system As we age, our immune systems begin to decline due to many factors, including the thymus shrinking and producing ever-fewer T cells, the ever-increasing chronic inflammation called “inflammaging”,…

Today, we want to point out a new study suggesting that senescent cells in bone marrow cell populations contribute to the decline of the hematopoietic system, particularly the hematopoietic stem and progenitor cells (HSPCs) that live in the bone marrow and produce our blood cells [1]. The hematopoietic system and immunosenescence The hematopoietic system is…

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