Building upon previous studies, a new study has unearthed critical facts about the basic biology behind the TORC1 pathway, identifying how caloric restriction leads to a chain of effects that involve the protein Maf1, RNA transcription, and, ultimately, genomic instability, which is one of the primary hallmarks of aging. A long chain of causes While…

This time on LE 101, Veera discusses another primary hallmark of aging, epigenetic alterations, which affect the switches that turn genes on and off – and may be surprisingly easy to reverse.

A new paper on senescent cells and aging brings together the current knowledge on the subject and presents it in a handy review format. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they…

DNA damage, which results in genomic instability, is one of the primary hallmarks of aging. Today, we want to highlight an recent open access review that explores the DNA damage response during aging. The role of DNA damage Some researchers have long suggested that damage to our DNA is a major reason why we age…

A new open access paper takes a look at tryptophan and the role that it plays in the dysfunction of the immune system in the context of the age-related changes that occur in the microbiome [1]. The microbiome The gut microbiome is a complex ecosystem of bacteria, archaea, eukarya, and viruses that live inside of…

After experiencing financial issues, DNA testing company Veritas Genetics has announced the suspension of its U.S. operations in an unexpected announcement on December 4th 2019. The company is perhaps best known for being co-founded by renowned Harvard University geneticist George Church and has been working towards reducing the costs of genome sequencing so that it…

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