The October Journal Club focused on a new study in worms where a combination of compounds acted in synergy to almost double lifespan. SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We show that…

The October Journal Club will be focusing on a new study in worms where a combination of compounds acted in synergy to almost double lifespan. SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We…

This month, we decided to do the Journal Club a bit earlier than usual to coincide with the launch of the NAD+ Mouse Project over at Lifespan.io. As the project is testing to see if NAD+ repletion increases lifespan, we thought that it would be an ideal time to explore NAD+ biology and take a…

This month, we decided to do the Journal Club a bit earlier than usual to coincide with the launch of the NAD+ Mouse Project over at Lifespan.io, which launches on September 18th. As the project is testing to see if NAD+ repletion increases lifespan, we thought that it would be an ideal time to explore…

For the August Journal Club, we took a look at a new paper that shows inhibiting TGFβ can boost liver regeneration [1]. We also discussed another related paper from 2015 by Conboy et al. which showed regeneration in aged mice was possible if TGFβ was inhibited [2]. Taken together, the two papers both confirm that systemic…

For the August edition of the Journal club, we will be taking a look at this new paper which focuses on boosting liver regeneration by inhibition of TGFβ1. We will be streaming the Journal Club live from our Facebook page. Setting liver regeneration free The liver is an excellent model of organ regeneration; however, regeneration may…

The July edition of the Journal Club saw us taking a look at a recent paper that casts doubt and concern over the use of CRISPR/Cas9 for gene editing. The researchers raised concerns that using it may result in genomic damage, something that was missed by previous researchers working with this powerful gene editing tool….

The July edition of the Journal Club has us taking a look at a recent paper that casts doubt and concern over the use of CRISPR Cas9 for gene editing. The researchers raise concerns that using it may result in genomic damage, something that was missed by previous researchers working with the powerful gene editing…

For the June edition of Journal Club, we discussed the recent paper entitled “Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver“. We had also summarized the research in an article earlier this month. Summary Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and…

For the June edition of Journal Club, we will be taking a look at the recent paper entitled “Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver“. We summarized the research in an article earlier this month. Summary Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies…

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