This is part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases. Today, we will be looking at the hallmark of cellular senescence. What are senescent…

When we ask researchers when, in their opinion, the cures for aging will be ready, we often hear an optimistic answer: 20-25 years. As a well-informed optimist, I add another 10 years to this number, because wherever the therapies appear, it will take time for them to be distributed to other countries and become affordable….

Today, we are going to take a look at the emerging theory that inflammaging, a chronic, age-related background of inflammation, is caused by alterations to the populations of intestinal microbes. What is inflammaging? Inflammaging is a term coined to describe the chronic, smoldering background of inflammation that accompanies the aging process. It is constant, low-grade…

Today, as part of our series of articles that cover the Hallmarks of Aging, we are going to take a look at the role of proteins in cellular function and how they play a key role in aging. Proteins are essential for cellular function Proteins are large, complex molecules that regulate almost everything in your…

Welcome to part two of a two-part series exploring NAD+ biology; you can find part one here. There are already a myriad of excellent reviews on NAD+ biology in general [1-3], so, in this article, we will be mainly focusing on the NAD+ precursor nicotinamide mononucleotide (NMN). NMN and synthesis of NAD+ NMN can be…

The aging process is accompanied by a chronic, smoldering background of inflammation that researchers call “inflammaging”. This backdrop of low-grade inflammation contributes significantly to mortality risk in the elderly and has a number of sources. Today, we are going to take a look at inflammaging and the various known sources that promote this age-related inflammatory…

This is part one of a two-part article where we take a look at NAD+ biology, its history, how it relates to the biology of aging, and the potential for therapeutic interventions via the so-called NAD+ precursors. What is NAD+? Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a…

Today, as part of our ongoing series covering the hallmarks of aging, we are taking a look at nutrient sensing and how its four pathways regulate metabolism and influence aging. The four associated key protein groups are IGF-1, mTOR, sirtuins, and AMPK. We call these proteins “nutrient sensing” because nutrient levels influence their activity. IGF-1…

Aging is something that we all share, rich or poor; it is something that happens to us all, and we are taught from a young age that it is inevitable. However, some scientists believe that aging is amenable to medical intervention and that such interventions could be the solution to preventing or reversing age-related diseases….

The topic of healthspan is increasingly being raised in the popular media, but what does it really mean? Simply put, healthspan means the period of your life in which you remain healthy and free from age-related diseases. The Roman poet Virgil once said “The greatest wealth is health”, so the concept of healthspan was something…

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