As part of our ongoing series covering the hallmarks of aging, we are taking a look at deregulated nutrient sensing today and how these four pathways regulate metabolism and influence aging. To understand studies on nutrient sensing in the context of aging, let’s introduce four key protein groups. In this post, we’ll explore the pathways they…

Aging is something that we all share, rich or poor; it is something that happens to us all, and we are taught from a young age that it is inevitable. However, some scientists believe that aging is amenable to medical intervention and that such interventions could be the solution to preventing or reversing age-related diseases….

The topic of healthspan is increasingly being raised in the popular media, but what does it really mean? Simply put, healthspan means the period of your life in which you remain healthy and free from age-related diseases. The Roman poet Virgil once said “The greatest wealth is health”, so the concept of healthspan was something…

This is the third part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases[1]. Today, we will be looking at one of the primary hallmarks, telomere…

Firstly, it greatly depends on how you define immortality. If you define it as living forever and being indestructible as in a comic book, then, no, it is highly unlikely. However, if you define it in terms of showing no decline of survival characteristics, no increase in disease incidence and no increase in mortality with…

This is the second part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into a number of distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases[1]. Today, we will be looking at one of the…

We are doing a series of articles that discuss the Hallmarks of Aging. Published in 2013, this paper is highly regarded in academia and is one of the most cited papers in biology, with an average of being cited once every two days. The paper divides aging into distinct categories (“hallmarks”) of damage to explain…

Autophagy means “eating of self” (from Ancient Greek “autó”= self;  and “phagein” = to devour)[1]. Although its name might sound harmful, autophagy appears to have longevity-promoting effects[2]. Here we will explain what autophagy is, how it works, its benefits, and how it plays a role in aging. What is Autophagy? Autophagy is the way cells…

The immune system as a whole can be broadly separated into two main branches: the innate immune response and the adaptive immune response. The innate immune response is performed by a system that is always present across the body, while the adaptive immune response appears only in response to an infection and is always specific…

Coming from a fusion of the words ‘protein’ (a molecule that a cell uses as a machine or scaffolding) and ‘stasis’ (meaning to keep the same), the term ‘proteostasis’ can essentially be simplified into “Each function reliant on proteins is running as it should. There are enough proteins to serve a function, and the concentrations…

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