For the November episode of the Journal Club, Dr. Oliver Medvedik will be reviewing a new study from a team of researchers including Professor George Church. The study saw the deployment of a multiple target gene therapy focused on 3 known longevity genes delivered via an adeno-associated virus. The focus was on mitigating T2 diabetes, heart failure,…

The Journal club returned for a Halloween special and Dr. Oliver Medvedik looked at a recent paper which showed a combination of three drugs had a synergistic effect and increased lifespan greatly in fruit flies. The drugs all target parts of the nutrient sensing system which controls metabolism and its deregulation is proposed to be…

The Journal club returns for a Halloween special and this time around, Dr. Oliver Medvedik is taking an in depth look at a recent paper which showed a combination of three drugs had a synergistic effect and increased lifespan greatly in fruit flies. The drugs all target parts of the nutrient sensing system which controls…

The topic for the September Edition of the Journal Club was the recent human trial of senolytic agents Dastatinib and Quercetin. For the researchers at the Mayo Clinic this was a follow on study from their previous human trial targeting IPF. This time the researchers ran a study to see how senolytics influenced diabetic kidney…

For the September Journal Club, we are taking a look at the new human trial data from the recent senolytics trial at Mayo Clinic, a follow-on study from its previous human trial targeting IPF. This time, the researchers ran a study to see how senolytics influenced diabetic kidney disease and if it actually removes senescent…

The Journal Club on August 27 was hosted by Dr. Oliver Medvedik and special guest Dr. Alexander Tyshkovskiy, who works at the Gladyshev at Brigham and Women’s Hospital, Harvard Medical School, Boston. The topic was the recent paper “Identification and Application of Gene Expression Signatures Associated with Lifespan Extension” published in Cell Metabolism. This study…

Journal Club will be returning on August 27 with your host Dr. Oliver Medvedik and special guest Alexander Tyshkovskiy, a Ph.D. student who works at the Gladyshev at Brigham and Women’s Hospital, Harvard Medical School, Boston. The topic for the journal club this month will be the recent paper “Identification and Application of Gene Expression Signatures Associated…

The July journal club hosted by Dr. Oliver Medvedik looked at the recent SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity. The study took a deep dive into SIRT6 in multiple species and how it appears to support longevity to a lesser or greater extent…

The journal club hosted by Dr. Oliver Medvedik returns for July and takes a look at the new SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity. Join us at 13:00 EDT on our Facebook channel where we will be livestreaming the show and discussing this interesting…

For the June edition of Journal Club, Dr. Oliver Medvedik and guests took a look at the recent human trial of urolithin A, a metabolite produced by microflora and an active ingredient in pomegranates that is linked to increased levels of mitophagy in aged animals. Urolithin A is a byproduct created when bacteria in the…

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