The March Journal Club hosted by Dr. Oliver Medvedik will focus on this recent study that showed transplanting the bone marrow of young laboratory mice into old mice prevented cognitive decline in the old mice, preserving their memory and learning abilities. These findings support the idea that cognitive decline is in part due to the aging of…

The February journal club focused on the recent paper “Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances”. Hosted by Dr. Oliver Medvedik, we were joined by study author, Dr. Peter Joshi from the University of Edinburgh, UK, who guides us through this fascinating genomics study of human…

The February journal club will focus on the recent paper “Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances”. Hosted by Dr. Oliver Medvedik, we will be joined by study authors, Dr. Peter Joshi and Paul Timmers both from the University of Edinburgh, UK who will guide us through this…

For the January Journal Club, we discussed the recent human senolytics trial conducted at the Mayo Clinic. Abstract Background Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively ablating senescent cells using dasatinib plus quercetin…

For the January Journal Club, we will be taking a look at the recent human senolytics trial conducted at the Mayo Clinic. Abstract Background Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively…

The topic for the December Journal Club was the recently published paper Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement, a plant-based polyphenol, appears to influence aging in mice by clearing senescent cells, which are one of the hallmarks of aging. There is certainly plenty of justification for moving this compound…

The topic for the December Journal Club will be the recently published paper – Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement and a plant-based polyphenol appears to influence the aging process in mice by clearing senescent cells, one of the suggested reasons we age. There is certainly plenty of justification…

Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. Dr. Oliver Medvedik, Steve Hill, and Victor Bjoerk discussed this interesting study…

Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. We will see you live on our Facebook page at 13:00 EST for…

The October Journal Club focused on a new study in worms where a combination of compounds acted in synergy to almost double lifespan. SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We show that…

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