This month, we decided to do the Journal Club a bit earlier than usual to coincide with the launch of the NAD+ Mouse Project over at Lifespan.io, which launches on September 18th. As the project is testing to see if NAD+ repletion increases lifespan, we thought that it would be an ideal time to explore…

For the August Journal Club, we took a look at a new paper that shows inhibiting TGFβ can boost liver regeneration [1]. We also discussed another related paper from 2015 by Conboy et al. which showed regeneration in aged mice was possible if TGFβ was inhibited [2]. Taken together, the two papers both confirm that systemic…

For the August edition of the Journal club, we will be taking a look at this new paper which focuses on boosting liver regeneration by inhibition of TGFβ1. We will be streaming the Journal Club live from our Facebook page. Setting liver regeneration free The liver is an excellent model of organ regeneration; however, regeneration may…

The July edition of the Journal Club saw us taking a look at a recent paper that casts doubt and concern over the use of CRISPR/Cas9 for gene editing. The researchers raised concerns that using it may result in genomic damage, something that was missed by previous researchers working with this powerful gene editing tool….

The July edition of the Journal Club has us taking a look at a recent paper that casts doubt and concern over the use of CRISPR Cas9 for gene editing. The researchers raise concerns that using it may result in genomic damage, something that was missed by previous researchers working with the powerful gene editing…

For the June edition of Journal Club, we discussed the recent paper entitled “Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver“. We had also summarized the research in an article earlier this month. Summary Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and…

For the June edition of Journal Club, we will be taking a look at the recent paper entitled “Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver“. We summarized the research in an article earlier this month. Summary Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies…

Earlier this month, there was a human clinical trial of the supplement MitoQ, which showed some interesting results. We thought that we would take a look at the data, and discuss the findings. Literature [1] Rossman, M. J., Santos-Parker, J. R., Steward, C. A., Bispham, N. Z., Cuevas, L. M., Rosenberg, H. L., … &…

Earlier this month, we covered a recent human clinical trial of the supplement MitoQ, which showed some interesting results. We thought that we would explore the publication a bit deeper, take a look at the figures, and discuss the findings in this month’s Journal Club. You can find the publication here. Abstract Excess reactive oxygen…

In April, we talked about new Alzheimer’s research showing how the gene variant ApoE4 greatly increases the risk of developing the disease, and we discussed how researchers have converted the defective gene back to its original form to cut the risk of Alzheimer’s.

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