Building upon previous studies, a new study has unearthed critical facts about the basic biology behind the TORC1 pathway, identifying how caloric restriction leads to a chain of effects that involve the protein Maf1, RNA transcription, and, ultimately, genomic instability, which is one of the primary hallmarks of aging. A long chain of causes While…

This time on LE 101, Veera discusses another primary hallmark of aging, epigenetic alterations, which affect the switches that turn genes on and off – and may be surprisingly easy to reverse.

A new paper on senescent cells and aging brings together the current knowledge on the subject and presents it in a handy review format. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they…

DNA damage, which results in genomic instability, is one of the primary hallmarks of aging. Today, we want to highlight an recent open access review that explores the DNA damage response during aging. The role of DNA damage Some researchers have long suggested that damage to our DNA is a major reason why we age…

A new open access paper takes a look at tryptophan and the role that it plays in the dysfunction of the immune system in the context of the age-related changes that occur in the microbiome [1]. The microbiome The gut microbiome is a complex ecosystem of bacteria, archaea, eukarya, and viruses that live inside of…

After experiencing financial issues, DNA testing company Veritas Genetics has announced the suspension of its U.S. operations in an unexpected announcement on December 4th 2019. The company is perhaps best known for being co-founded by renowned Harvard University geneticist George Church and has been working towards reducing the costs of genome sequencing so that it…

A type of artificial intelligence technique is now being used to develop new drugs and therapies and could perhaps even help to solve aging. An urgent need for aging biomarkers There has long been an urgent need in our field to develop increasingly accurate biomarkers of aging so that the efficacy of interventions can be…

If humans ever reach an average lifespan of well over 100 years, what is going to happen? Are we going to be bored with such long lives? “Well,” says Prof. Brian Kennedy of the National University of Singapore, “If you ask me: ‘Do I want to have cancer at 75? Do I want have Alzheimer’s…

A new study suggests that harmful changes to the population and diversity of our gut bacteria may occur when we are as young as our mid 30s, which can have serious implications for health and longevity. The microbiome The gut microbiome is a complex and ever-changing ecosystem populated by a myriad of archaea, eukarya, viruses,…

Researcher Dr. Michael Lustgarten has recently published a compact and very readable review that focuses on the role of the gut microbiome and its influence on skeletal muscle mass. The gut microbiome The microbiome describes a varied community of bacteria, archaea, eukarya, and viruses that inhabit our gut. The four bacterial phyla of Firmicutes, Bacteroidetes,…

© 2018 - LIFE EXTENSION ADVOCACY FOUNDATION
Privacy Policy / Terms Of Use

       Powered by MMD