The immune system is like an army keeping us safe from invasion, injury and infection and helps us to regenerate and repair tissues and organs. However, the immune system is sometimes a double-edged sword that does more harm than good. A lot of focus has been on the role of macrophages and their ability to…

One of the most intriguing questions in biology discusses why some animals can regenerate their major body parts, such as hearts and limbs, and others cannot. A new study led by Dr. James Godwin from the MDI Biological Laboratory suggests that the innate immune system could be the answer. Secrets revealed in salamander study A…

The cost of drug discovery and subsequent development is a massive challenge in the pharmaceutical industry. A typical drug can cost upwards of $2.5 billion and a decade or more to identify and test a new drug candidate[1]. In this article, we will be taking a look at the spiraling costs of drug development and…

We are pleased to hear that the SENS Research Foundation has announced a new research program in collaboration with the Spiegel lab at Yale University. This new project is a continuation of their work with the crosslink glucosepane and sees them moving towards effective ways to remove it from the body to address age-related diseases. …

PCSK9 inhibitors, a new type of therapy, has arrived and appear to be an effective therapy for lowering LDL cholesterol to a level that exceeds the current standard of care. Recently, the results from a clinical trial at Brigham and Women’s Hospital showed that the drug evolocumab, when combined with statins, significantly and safely reduced…

By treating one of the root causes of aging – senescent cells – a new class of drugs, known as senolytics, has the potential to treat a wide range of age-related diseases rather than the traditional approach of dealing with them one at a time.  Today we are going to take a look at what…

It has long been accepted that people and other primates are born with the ability to recognize faces; however, a new study at Harvard Medical School has brought that into question. The study findings suggest that facial recognition is not innate but is learned The new study published in Nature Neuroscience worked with macaques that…

Osteoporosis is a crippling condition provoked by an imbalance between the creation of new bone tissue and the destruction of the old, which becomes worse as we age. What causes osteoporosis to develop and progress? Osteoporosis is the failure of tissue maintenance in the bones, causing them to become weak and fragile. This increases the…

A new study published by scientists at the Salk Institute recently shows how that changes in the nucleolus of progeria cells and normally aged cells share some characteristics that may allow them to be used as a biomarker for biological age[1]. What is Progeria? Hutchinson-Gilford progeria is a rare genetic disease that causes people to…

If there was a poster child of aging diseases, it would be Alzheimer’s disease. The brains of people suffering from Alzheimer’s disease have deposits of amyloids resulting from the loss of proteostasis. Alzheimer’s disease is accompanied by the presence of amyloid beta protein and tau protein as well as large numbers of activated pro-inflammatory immune…

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