One extremely promising and emerging field of research is nano-biotechnology. Nano-biotechnology could potentially be an extremely powerful tool in our quest for a longer, healthier life. Senescent cells are known to be essential in multiple aging processes. Getting rid of these problem cells is, therefore, something we could do to potentially increase our healthy lifespan,…

Somewhat serendipitously, Salk Institute researchers discovered that depleting the microbiomes of mice causes the animals to have lower levels of blood glucose as well as improved insulin sensitivity [1]. Abstract Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role of the gut microbiome in pathological conditions. However, unlike germ-free mice, the effects…

Today, we wanted to draw your attention to a review of aging and the role that the gut microbiome plays in it. There is an increasing amount of evidence for the contribution of microbial burden in the chronic, age-related background of inflammation known as “inflammaging“. There are a number of proposed sources of inflammaging, including…

Researchers from the Walter and Eliza Hall Institute, the Monash Institute of Pharmaceutical Sciences, and Cancer Therapeutics CRC have developed a new type of drug that harnesses cellular senescence as a weapon against cancer [1]. Study abstract Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function. Among the genes coding…

Scientists at the Johns Hopkins University reversed hair whitening and loss associated with a high-fat, high-cholesterol diet by using an experimental compound in a mouse model [1]. The compound The experimental compound used by the researchers, called D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D–PDMP) acts by blocking the production of glucosphingolipids (GSL), which are lipids that are abundant in the…

Two studies by researchers at the University of Birmingham have shown that delivering drugs against the wet form of age-related macular degeneration (AMD) in the form of eyedrops might soon be possible in humans [1, 2]. What is age-related macular degeneration? AMD is a pathology of the retina, which is a light-sensitive tissue located in…

Today, we are pleased to announce that the results are in from a human trial that targets the aging immune system and that an immune system-boosting drug appears to be effective. Targeting TORC1 to boost the immune system As we age, the immune system becomes increasingly poor and unable to detect and fight infections. This…

Getting old is one thing; getting old in a healthy way is another. Many elderly people suffer from all kinds of diseases and disorders, ranging from cardiovascular problems and diabetes to Alzheimer’s and Parkinson’s disease. Wouldn’t it be nice if we could keep the body young as we grow older to prevent disease associated with…

In what appears to be a world first, scientists at the University of Alabama at Birmingham have reversed two of the most common visual signs of aging—skin wrinkles and hair loss—in mice by turning off a gene responsible for mitochondrial dysfunction [1]. Study abstract Mitochondrial DNA (mtDNA) depletion is involved in mtDNA depletion syndromes, mitochondrial…

Australian researchers have made a discovery about telomeres that may have implications for aging, heart disease, cancer, and other age-related diseases. So, what are telomeres?  Each of the chromosomes that store our genetic information has a telomere at each end. This protective cap consists of a specific DNA sequence that is repeated thousands of times…

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