A team of researchers, including Dr. David Sinclair, has recently made a new study available as a preprint prior to peer review and publication in the journal Cell. DNA damage and the double-strand break Two of the primary hallmarks of aging are genomic instability, which consists of damage to our DNA, and epigenetic alterations, which…

A recent study suggests that circulating glucuronic acid may be a useful predictor of both lifespan and healthspan in humans and mice. What is glucuronic acid? Glucuronic acid is a metabolite of glucose and is critical for the detoxification of xenobiotic substances. These are compounds that are not naturally produced, should not normally be in…

A small-scale human trial by Mayo Clinic researchers has shown for the first time that harmful senescent cells that accumulate with age can be removed from the body by senolytic drugs. This has been demonstrated many times already in mice, but this is the first confirmation that these drugs remove senescent cells in the same…

A role for the gut microbiome on the health and functioning of many tissues, including the brain, liver, kidney, and adiposity, has been widely reported in the literature. Interestingly, 2019 might be the year that the role of the gut microbiome on skeletal muscle (i.e. the gut-muscle axis) comes into greater focus. The influence of…

Researchers at the Buck Institute, including Dr. Judy Campisi, have published a new study that shows, for the first time, that senescent cells are associated with age-related blood clots [1]. As we get older, increasing numbers of our cells enter into a state known as cellular senescence. Senescent cells do not divide or support the…

A recent review shows the current state of the industry with regards to using human pluripotent stem cells (hPSCs) to create cells that are useful for the study of, and therapies for, the human heart. Pluripotent Stem Cells Stem cells are the cells that form every other cell in the body, and adult humans naturally…

Researchers from North Carolina State University have demonstrated that exosomes harvested from human skin cells can repair sun-damaged skin cells in mice. The therapy also appears to be more effective than retinol and stem cell treatment, and best of all, delivery of the therapy is needle-free. What are exosomes? Exosomes are essentially membrane-wrapped packages that…

The ability to create synthetic organs has long been desired in medicine. If we could make synthetic organs for patients from their own cells, we could replace injured or damaged organs without risking the body rejecting the organ. This would have huge implications for the treatment of liver and kidney diseases, among others. For years,…

A small clinical trial, which was conducted by a team of researchers led by Dr. Greg Fahy, has shown for the first time in humans that reversing biological age may be possible. The results of TRIIM are in The researchers spent a year running the Thymus Regeneration, Immunorestoration, and Insulin Mitigation (TRIIM) trial, which included…

A joint study by researchers at the National Institutes of Health (NIH) and the University of Maryland (UMD) has revealed a previously undocumented protective function of the telomerase enzyme. Telomerase is used by somatic cells too It was thought for a long time that telomerase is only active in certain cell types, such as stem…

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