Researchers have discovered a link between the cellular recycling system known as autophagy and the behavior of microglial immune cells during aging. We have discussed the polarization of macrophages in a number of previous articles, and it has become quite a hot topic among researchers in the last few years. Microglia are tissue-resident macrophages in…

Cytomegalovirus (CMV) is a β-herpesvirus that infects the majority of people in the world. It lies dormant in the body, waiting for an opportunity to strike when the immune system is weakened. This persistent virus infects people for their entire lives, and now researchers have discovered how the virus spreads, opening the door to ways…

A study by scientists at the Research Institute of the McGill University Health Centre unveiled a mechanism through which deadly glioblastomas can metastasize. The research has been published in Molecular & Cellular Proteomics [1]. Abstract Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of…

Researchers from Scripps Research have discovered how the proteasome, which is made of protein complexes in the cell that breaks down damaged and unwanted proteins, converts energy into motion to unfold target proteins for recycling. What is the proteasome? The proteasome is a protein complex whose job is to break down and recycle proteins that…

A number of therapies that directly target the aging processes are currently in human trials and could change medicine significantly in the next decade if the results are positive. What is aging? Aging is basically the accumulation of damage and errors caused by a collection of varied processes that harm the functions of the body…

Today, we want to highlight results from human trials in which stem cell transplants have been shown to reduce age-related frailty. Age-related frailty and stem cell transplants Currently, there are no specific approved therapies to address age-related frailty, which can cause elderly people to suffer potentially fatal falls and injuries. There has been considerable interest…

Today, we want to discuss this review published in the journal Science, as it provides a whistle-stop tour of caloric restriction, intermittent fasting, and time-restricted feeding. There is a considerable amount of data supporting the effects of caloric restriction and similar dietary approaches on both health and lifespan in multiple species. In general, the more…

Today, we want to point out a new study showing how senescent cells poison their healthy neighbors and that the more there are, the faster they make other cells become senescent. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide…

Today, we want to highlight a study that shows the link between atherosclerosis and the age-related shrinking of the thymus, which is arguably the most important organ of the immune system [1]. The adaptive and innate immune systems and atherosclerosis The thymus is essentially like an army base where new T cells develop and are…

In a world first, a patient with Parkinson’s disease has undergone transplant therapy, which uses reprogrammed stem cells to replace neurons destroyed by the disease. Stem cell therapy is part of the toolkit The stem cell field is an area of science that is relatively well funded and, out of all the branches of medical…

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