In a small, recent human trial, a naturally occurring compound called urolithin A has yielded positive results and appears to slow down part of the aging process that is related to the production of energy in our cells. What is urolithin A? Urolithin A is the end product created when bacteria in the gut break…

Recently, Unity Biotechnology completed a phase 1 trial of its drug UBX0101. While the trial found that the drug was non-toxic and lacked serious side effects, many of its results were not statistically significant. UBX0101 UBX0101 aims to treat osteoarthritis and possibly other diseases of aging through directly targeting one of the aspects of aging…

In a new study, researchers have found that the zinc-finger transcription factor Slug is responsible for repressing p16Ink4a, a compound that promotes senescence in human tissue. The researchers suggest that Slug is worth exploring as a treatment for sarcopenia [1]. Satellite cells Satellite cells are specialized stem cells that form new muscle cells when the…

Today, we want to point out a new publication that recently appeared in the Science Translational Medicine journal, as its authors have discovered a new mechanism by which the brain protects itself from the harmful α-synuclein protein aggregates associated with Parkinson’s and that may open the door to new therapies against these conditions. To understand…

A new publication highlights how the complex interaction of NAD+ and cellular senescence pathways may complicate proposed anti-aging therapies that boost NAD+ using precursors. What are epigenetic alterations? One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations….

The gut microbiome appears to be increasingly responsible for at least some of the decline of the immune system during aging, and a new mouse study shows that it is reversible. The gut microbiome The microbiome describes a varied community of bacteria, archaea, eukarya, and viruses that inhabit our guts. The four bacterial phyla of…

Today, we wish to highlight a new open access publication in which the researchers take a novel approach to the regeneration of the thymus, a small but vitally important organ that is key to our immune system. The thymus shrinks as we age The thymus is one of the most important organs in the body,…

A group of Spanish researchers, including Dr. Maria Blasco and others at the CNIO, have published a new study that examines the consequences of short telomeres and telomerase deficiency on the brain [1]. This study addresses an aspect of telomere attrition, one of the primary hallmarks of aging. Telomeres are repeating sequences of DNA (TTAGGG)…

The researchers of a new publication take a look at the effects of obesity on aging and consider its impact in the context of the Hallmarks of Aging, a popular theory that breaks down aging into nine distinct processes. The case for obesity accelerating aging Being overweight and carrying excessive amounts of visceral fat, a…

In a new study, researchers at the University of Pécs, Hungary used cell secretions known as exosomes to regenerate the thymus, one of the most important organs in the body. The thymus shrinks as we age The thymus is arguably one of the most critical organs in the body, and it is where new T…

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