Researchers have demonstrated that telomerase gene therapy does not increase the risk of cancer, even in strains of mice that are particularly susceptible to cancer [1]. A tale of telomeres Short telomeres trigger cellular senescence and are thought to be one of the primary hallmarks of aging, which has led to various researchers seeking ways…

Today, we wanted to draw your attention to a recent study showing an association between the accumulation of Tau proteins, which are misfolded proteins that typically indicate Alzheimer’s disease and senescent cells. The researchers also showed that Tau pathology was improved by the use of drugs that remove non-dividing senescent cells. Unfortunately, this journal paper…

Today, we would like to share with you the talk given by Kelsey Moody, CEO of Biotech Company Ichor, at the recent Ending Age-Related Diseases: Investment Prospects & Advances in Research conference in New York City. In this talk, Kelsey discusses Ichor’s protein engineering platform, how Ichor has used it, and Ichor’s plans for using it to…

One extremely promising and emerging field of research is nano-biotechnology. Nano-biotechnology could potentially be an extremely powerful tool in our quest for a longer, healthier life. Senescent cells are known to be essential in multiple aging processes. Getting rid of these problem cells is, therefore, something we could do to potentially increase our healthy lifespan,…

Somewhat serendipitously, Salk Institute researchers discovered that depleting the microbiomes of mice causes the animals to have lower levels of blood glucose as well as improved insulin sensitivity [1]. Abstract Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role of the gut microbiome in pathological conditions. However, unlike germ-free mice, the effects…

Today, we wanted to draw your attention to a review of aging and the role that the gut microbiome plays in it. There is an increasing amount of evidence for the contribution of microbial burden in the chronic, age-related background of inflammation known as “inflammaging“. There are a number of proposed sources of inflammaging, including…

Researchers from the Walter and Eliza Hall Institute, the Monash Institute of Pharmaceutical Sciences, and Cancer Therapeutics CRC have developed a new type of drug that harnesses cellular senescence as a weapon against cancer [1]. Study abstract Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function. Among the genes coding…

Scientists at the Johns Hopkins University reversed hair whitening and loss associated with a high-fat, high-cholesterol diet by using an experimental compound in a mouse model [1]. The compound The experimental compound used by the researchers, called D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D–PDMP) acts by blocking the production of glucosphingolipids (GSL), which are lipids that are abundant in the…

Two studies by researchers at the University of Birmingham have shown that delivering drugs against the wet form of age-related macular degeneration (AMD) in the form of eyedrops might soon be possible in humans [1, 2]. What is age-related macular degeneration? AMD is a pathology of the retina, which is a light-sensitive tissue located in…

Today, we are pleased to announce that the results are in from a human trial that targets the aging immune system and that an immune system-boosting drug appears to be effective. Targeting TORC1 to boost the immune system As we age, the immune system becomes increasingly poor and unable to detect and fight infections. This…

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