In a study published in the journal Immunology, Southampton University researchers have shown that a new antibody that they have engineered is able to combine two different anticancer approaches: depleting regulatory T cells and activating killer T cells [1]. Abstract The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies…

We wanted to bring your attention to a recent publication that discusses the topic of cellular senescence and the contributions of senescent cells to aging and disease [1]. What is perhaps the most interesting part of this paper is the section covering the potential future directions that researchers may take in managing senescent cell populations…

Researchers at Georgetown University Medical Center discovered that the protease USP13 (ubiquitin-specific peptidase 13) plays a role in the accumulation of toxic alpha-synuclein aggregates that characterize Parkinson’s disease [1]. Abstract Ubiquitin specific proteases (USPs) are de-ubiquitinases that control the protein ubiquitination cycle. The role of de-ubiquitinases is poorly understood in neurodegenerative diseases. We found that…

Researchers at the Salk Institute have published new data showing that a number of Alzheimer’s drug candidates based on the supplements fisetin and curcumin also appear to slow aging in mice. Targeting aging directly to prevent disease If old age is the single most significant risk factor for diseases such as Alzheimer’s, then it makes…

A new study takes a look at the relationship between metabolism, aging, and type 2 diabetes and in particular the mTORC1 protein complex, part of the mTOR pathway. The mTOR pathway The mechanistic target of rapamycin (mTOR) pathway is a major part of metabolism and is one of four major pathways that control it; collectively,…

Researchers from the Kapahi Lab at the Buck Institute for Research on Aging have shown in a new study that increased intestinal permeability is caused by the age-related loss of epithelial cells that form the gut membrane [1]. As we age, the integrity of the gut membrane declines, and it becomes more permeable; this is…

Today, we want to highlight a new study that used in silico analysis to look at the interaction between metformin and SIRT1 [1]. SIRT1 and metabolism Silent mating type information regulation 2 homolog (SIRT1) is a member of the sirtuin protein family, and studies suggest that human sirtuins act as intracellular regulatory proteins. Sirtuin 1…

A new palm-sized testing system has been developed to measure the levels of aging biomarkers circulating in the body. The new biomarker system, called Click-A+Chip, was developed by Sarah Balderston and Mandeep Sandhu, who are part of the Keck Graduate Institute team led by Assistant Professor of Medical Diagnostics and Therapeutics Kiana Aran. This miniature…

Through a new approach dubbed AMBAR, the biotechnology company Grifols has attempted to reduce the amount of harmful, Alzheimer’s disease-causing amyloid beta in the brain by collecting it with a blood protein called albumin and draining it out of the bloodstream. This approach differs from the previous antibody and catabody approaches and offers new hope…

A new study suggests that NAD+, which declines with age, may be increased via the de novo pathway. This is potentially interesting as it presents an alternative way in which to elevate NAD+ levels versus the better-known approach of using NAD+ precursors such as NR and NMN. What is NAD? Nicotinamide adenine dinucleotide (NAD) is…

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