Thanks to a new technique, researchers from the Salk Institute’s Gage laboratory have shown that impaired energy production might be a reason why human brains are susceptible to age-related diseases in the first place [1]. In particular, Salk scientists observed that induced neurons (iNs) obtained from fibroblasts of older individuals had dysfunctional mitochondria and therefore…

Researchers at the National University of Singapore (NUS) have potentially found a new way to combat hypertension by discovering how blood pressure is controlled. What is hypertension? High blood pressure, or hypertension, rarely has noticeable symptoms. However, if it is left untreated, your risk of serious problems, such as heart attack and stroke, is increased….

A new study suggests that autophagy, the recycling, and disposal system that cells use to remove unwanted garbage, can extend the healthy lifespan of mammals. The study, led by Drs. Salwa Sebti and Alvaro Fernández from the Center for Autophagy Research, has discovered that mice with higher levels of autophagy live longer and healthier than…

Two papers by Partridge et al [1, 2], both published in 2009, provide the somewhat rare opportunity to examine some concerns about life extension as formulated by actual people, rather than their general, more abstract forms. As highlighted in the studies, research on the public’s perception of life extension science has been very much neglected;…

Researchers at the University of Virginia School of Medicine have discovered that as we age, our cells’ nuclear membranes become misshapen, which stops our genes from working properly. Nuclear membranes become distorted with age The DNA in all our cells is the same; however, the cells in our body show a great range of variation…

A substance found in aspirin has been demonstrated to replicate certain beneficial aspects of caloric restriction. Introduction Macroautophagy (hereafter referred to as autophagy) acts as a homeostatic pathway at both the cellular and organismal levels (Mizushima and Komatsu, 2011). The finely tuned execution of this multistep process (ensured by the coordinated activity of specifically committed Atg…

Vascular risk appears to be a strong predictor of dementia, especially in older individuals with high levels of brain beta-amyloids, and the interaction between these two risk factors might lead to a higher rate of cognitive decline, according to a recent study at the Massachusetts General Hospital. Alzheimer’s disease (AD) is an age-related neurological disorder…

Researchers from the University of Texas have discovered how NAD+ creation and consumption in cells is linked to glucose metabolism and their transformation from preadipocytes into adipocytes, or as most people know them, fat cells. INTRODUCTION Nicotinamide adenine dinucleotide (NAD) is an essential small molecule that is involved in a variety of physiological and pathological processes….

Researchers at Brown University have discovered a way to stimulate cellular autophagy, which is a natural recycling system built into every cell in the body. This has the potential to combat many age-related neurodegenerative diseases. What is autophagy? Autophagy means “eating of self” (from Ancient Greek “auto” = self, “phagein” = to devour). Autophagy is…

Researchers from the National Cancer Institute (NCI), the University of Kansas, and the National Center for Advancing Translational Science (NCATS) have discovered a compound that can block the spread of some types of cancer cells. Preventing cancer metastasis Metastasis is how cancer spreads from an initial site to a secondary site within the host’s body;…

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