Today, we will take a look at the popular supplement fisetin and see how it stacks up as a geroprotector. History of Fisetin Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its…

History of Metformin Metformin was originally discovered in 1922, but it did not receive approval for another fifty years or more[1]. The French physician Jean Sterne initiated the first study in humans in the 1950s; it was registered as a medicine in France in 1957, but it was not approved until 1995 in the United…

They say you can’t buy happiness, but you can buy wine, and that’s kind of the same thing. But could drinking wine also be adding years to your life? A small compound known as resveratrol might hold the key to this question. History Grapes have been hailed as a miracle cure since 1928, when Johanna…

Meat is rich in creatine, an important energy buffer in muscle cells, and the main constituent of a popular sports supplement used by athletes. However, we’re now finding out that there’s more to creatine than ‘meats’ the eye. To be clear, it is not a good idea to wolf down loads of steaks, sausages, bacon….

History Arginine was first isolated from the extract of lupin seedlings by the German chemist Ernst Schultze in 1886. Arginine in nature Arginine is found naturally in a variety of foods, including turkey, pork, chicken, pumpkin seeds, soybeans, peanuts, spirulina, chickpeas, and lentils. Potential health benefits Arginine (also known as L-Arginine) is an important amino…

History Niacin is a form of water-soluble vitamin B3. In 1937, this vitamin was discovered in yeast and meat by American biochemist Conrad Elvehjem. It was found to cure pellagra, a disease that is caused by vitamin B3 deficiency and that causes horrible skin lesions, diarrhea, dementia, and even death. This compound is now commonly…

Alpha-lipoic acid is a common supplement, but what about its geroprotective properties? We take a look at this supplement in another of our geroprotector articles. History Alpha-lipoic acid (ALA) was first discovered in 1937, when Snell discovered that a type of bacteria relied on potato juice to reproduce[1]. This led to alpha-lipoic acid being known…

Magnesium is a common element and is found in a variety of foods, but not everyone gets enough of this essential element which is vital for cellular processes. History of Magnesium It was Joseph Black who recognized magnesium as an element back in 1755. However, it was first isolated by Sir Humphry Davy in only 1808….

Today, we take a look at one of the more unusual supplements that has been used in traditional medicine for many years. History of honokiol Honokiol is a lignan isolated from the bark, seed cones, and leaves of the trees of various Magnolia species. Honokiol, along with other active molecules in magnolia, such as magnolol…

Glucosamine is one of the most commonly used supplements frequently taken to promote joint health and treat other aches, but there really is more to this dietary supplement than first meets the eye. History of glucosamine Glucosamine was originally discovered during the 1960s in Italy, by pharmacologist Professor Luigi Rovati, the founder of pharmaceutical giant…

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