Dr. Amutha Boominathan
SENS Research Foundation
Dr. Boominathan is the Group Lead for the MitoSENS program at SENS Research Foundation (SRF), Mountain View, California. She obtained her PhD in Biochemistry from National Chemical Laboratory, India and subsequently had her postdoctoral training at University of Pennsylvania and Rutgers University. As an American Heart Association Postdoctoral Fellow, she studied protein import into mitochondria, Fe-S cluster biosynthesis and mechanisms of fusion and fission in mitochondria. With more than 18 years of experience in mitochondrial biogenesis, she leads a highly motivated team of researchers at SRF in furthering our understanding and developing therapies for myopathies from mitochondrial DNA (mtDNA) mutations.
Both inherited and acquired mutations in mtDNA are the cause for several diseases including LHON, Leigh’s syndrome, MELAS, MEERF, and NARP. mtDNA mutations also accumulate with age and accompany a progressive decline in organelle function. The goal of the Boominathan lab is to express functional copies of the mtDNA genes from the nucleus via allotopic expression and ultimately develop tangible therapies for mitochondrial dysfunction.