This month, we decided to do the Journal Club a bit earlier than usual to coincide with the launch of the NAD+ Mouse Project over at Lifespan.io, which launches on September 18th. As the project is testing to see if NAD+ repletion increases lifespan, we thought that it would be an ideal time to explore NAD+ biology and take a look at a recent publication by Dr. David Sinclair. Join us on September 18th at 1:00 PM Eastern Time / 6:00 PM UK time as we stream the show live on our Facebook page.
Nicotinamide adenine dinucleotide (NAD), the cell’s hydrogen carrier for redox enzymes, is well known for its role in redox reactions. More recently, it has emerged as a signaling molecule. By modulating NAD+-sensing enzymes, NAD+ controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD+ levels steadily decline with age, resulting in altered metabolism and increased disease susceptibility. Restoration of NAD+ levels in old or diseased animals can promote health and extend lifespan, prompting a search for safe and efficacious NAD-boosting molecules that hold the promise of increasing the body’s resilience, not just to one disease, but to many, thereby extending healthy human lifespan.
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell metabolism, 27(3), 529-547.