Share

This month, we decided to do the Journal Club a bit earlier than usual to coincide with the launch of the NAD+ Mouse Project over at Lifespan.io, which launches on September 18th. As the project is testing to see if NAD+ repletion increases lifespan, we thought that it would be an ideal time to explore NAD+ biology and take a look at a recent publication by Dr. David Sinclair. Join us on September 18th at 1:00 PM Eastern Time / 6:00 PM UK time as we stream the show live on our Facebook page.

Abstract

Nicotinamide adenine dinucleotide (NAD), the cell’s hydrogen carrier for redox enzymes, is well known for its role in redox reactions. More recently, it has emerged as a signaling molecule. By modulating NAD+-sensing enzymes, NAD+ controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD+ levels steadily decline with age, resulting in altered metabolism and increased disease susceptibility. Restoration of NAD+ levels in old or diseased animals can promote health and extend lifespan, prompting a search for safe and efficacious NAD-boosting molecules that hold the promise of increasing the body’s resilience, not just to one disease, but to many, thereby extending healthy human lifespan.

Literature

Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell metabolism27(3), 529-547.

CategoryJournal club
About the author

Oliver Medvedik

Oliver Medvedik, Co-founder of Genspace citizen science laboratory in Brooklyn NY, earned his Ph.D. at Harvard Medical School in the Biomedical and Biological Sciences program. As part of his doctoral work he has used single-celled budding yeast as a model system to map the genetic pathways that underlie the processes of aging in more complex organisms, such as humans. Prior to arriving in Boston for his doctoral studies, he has lived most of his life in New York City. He obtained his bachelor’s degree in biology from Hunter College, City University of New York. Since graduating from Harvard, he has worked as a biotechnology consultant, taught molecular biology to numerous undergraduates at Harvard University and mentored two of Harvard’s teams for the international genetically engineered machines competition (IGEM) held annually at M.I.T.
  1. September 16, 2018

    I’ve read that NAD can be boosted by taking NMN, NR, NA (nicotinic acid), or NAM (nicotinamide). Apparently taking high doses of NAM will boost NAD, but it also inhibits Sirtuins. So that’s counterproductive. But the only common issue with taking NA is the flushing. So if you don’t mind the flushing (or don’t get much flushing), is there any reason not to boost NAD by taking high doses of NA?

Write a comment:

*

Your email address will not be published.

© 2018 - LIFE EXTENSION ADVOCACY FOUNDATION
Privacy Policy / Terms Of Use

       Powered by MMD