The topic for the December Journal Club was the recently published paper Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement, a plant-based polyphenol, appears to influence aging in mice by clearing senescent cells, which are one of the hallmarks of aging.
There is certainly plenty of justification for moving this compound to human trials where reliable data can be recorded and to see if the effects observed in mice and human cell lines are seen in people. We discuss how running human studies offers low-hanging fruit and could be reasonably easy and safe to do given its superb safety profile.
If you would like to take a look at the data yourself, you can find the open access paper here.
Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., … & McGuckian, C. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18-28.