Today, we have another update from Dr. Matthew “Oki” O’Connor, the MitoSENS lead researcher.

Hi everyone, it’s been an amazing few months. In short, we have been tremendously successful in our efforts to rescue a mutation in the mitochondrial genome!

PrintEssentially, we’ve shown that we can relocate both ATP6 and ATP8 to the nucleus and target the proteins to the mitochondria. We’ve shown that the proteins incorporate into the correct protein complex (the ATPase) and that they improve function, resulting in more ATP production. Finally, we’ve shown that the rescued cells can survive and grow under conditions that require mitochondrial energy production while the mutant cells all die.

We have finished writing up our results and submitted them for review and publication. It may take a while for our results to be published, as the peer review process can be lengthy, but as soon as they are, I’ll post an update here so that you can see the full paper.

We have also started the project on which you helped us get to our stretch goal. We have made all the combinations of MTS with ATP6 that we proposed and are now working on testing them. I’ll let you know when we know more.

Thank you so much for your support!


About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 500 articles on the topic as well as attending various medical industry conferences. In 2019 he was listed in the top 100 journalists covering biomedicine and longevity research in the industry report – Top-100 Journalists covering advanced biomedicine and longevity created by the Aging Analytics Agency. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, and, Keep me Prime, and New Economy Magazine. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project. In 2015 he led the Major Mouse Testing Program (MMTP) for the International Longevity Alliance and in 2016 helped the team of the SENS Research Foundation to reach their goal for the OncoSENS campaign for cancer research.
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