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Today, we have an update from the MMTP Project team. The project was launched on Lifespan.io back in 2016 with the aim of testing senolytics and their effect on lifespan, it was successfully funded and raised 15% over its initial goal.

Hi everyone, it has been a long time so we thought it was time for a small update. We wanted to let you all know that the mouse study is underway in Germany, although we have been significantly delayed due to the strict regulations in Europe concerning animal welfare.

In Europe, there is a lot of paperwork to complete and high standards to reach before permission is granted for an animal study. We are pleased to confirm that after meeting those strict standards, the study was launched earlier this year at a facility near Leipzig, Germany.

We are testing six different senolytic or potentially senolytic drugs in various combinations, as multiple previous tests on senolytics done by other groups suggest that each one favors a different cell type. There are no previous studies exploring the potential of combinations of senolytics, with the exception of the work done with dasatinib and quercetin.

Many of the compounds that we are testing are known to target different types of senescent cells; therefore, a combination could potentially improve their efficiency, as Dr. Peter de Keizer recently suggested when he discussed senolytic “cocktails”.

Thank you once again to all our generous supporters who helped make the project a reality, and we hope that it leads to some interesting results once the research team publishes its findings.

Thanks

The MMTP Team

About the author

Steve Hill

As a scientific writer and a devoted advocate of healthy longevity and the technologies to promote them, Steve has provided the community with hundreds of educational articles, interviews, and podcasts, helping the general public to better understand aging and the means to modify its dynamics. His materials can be found at H+ Magazine, Longevity reporter, Psychology Today and Singularity Weblog. He is a co-author of the book “Aging Prevention for All” – a guide for the general public exploring evidence-based means to extend healthy life (in press).
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