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The concern that rejuvenation biotechnologies might cause social disparity and further widen the gap between rich and poor is one of the most commonly raised ones, probably second only to concerns of overpopulation. Like many others, this concern may appear valid at first, but it does not survive careful analysis.

Anti-aging sticker shock

The underlying assumption of the argument we are discussing is that rejuvenation therapies would be so very expensive that only rich people would be able to afford them, thus fracturing the world into the ever-young, ever-healthy rich ones, and the poor, sick, old ones with no access to these technologies. It is very likely that rejuvenation therapies will be quite expensive (at least initially) due to a number of factors.

However, before we delve deeper into the details of this discussion, let’s remind ourselves of an important but possibly understated fact: rejuvenation biotechnologies are life-saving medical treatments, meant to prevent age-related diseases and allow people to maintain good health throughout their lives. In this sense, they are no different from antiviral or cancer therapies, prescribed and administered currently by doctors in appropriate healthcare facilities. So really just the same as any other life-saving treatment, the price is irrelevant in the face of the benefits they would confer to us, and certainly not a valid reason not to develop them.

However, even if we can initially assume a high cost for rejuvenation biotechnologies, we need to keep in mind that new technologies generally start off as very expensive and eventually become affordable and widespread. For instance, it took only 15 years for full genome sequencing cost to drop from $100 million to $300, making personalised medicine reality globally.

costpergenome2015_4

Fig 1. The Cost of Sequencing a Human Genome change, 2001-2015. Source: National Human Genome Research Institute

In the field of medicine, there are several other examples of this same trend of falling cost and prices. The drug Metformin, used for the treatment of type 2 diabetes (and probably the first drug to slow down aging in healthy people, which is currently the subject of TAME clinical trial), was initially expensive but eventually its price plummeted to a few dollars. Its price fell from $1.24 per tablet in 2002 to 31 cents in 2013. The infographic below shows some other examples of drugs that were once expensive and have subsequently fallen in cost.

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Similarly, improvements in technology have drastically reduced the costs of research diagnostics, and the advent of remote technology has allowed a cost reduction for both patients and hospitals as specialists can be contacted at a distance. As an example, this means hospitals do not need to have radiologists in location all the time, but can instead remotely send them patient data for analysis and thus only pay for each individual service; this, in turn, implies potentially cheaper services for the patients as well.

Even gene therapies, stem cell therapies and immunotherapies may soon become cheaper, less time-consuming, and consequently more widely available thanks to innovations such as this new semi-automated benchtop system that produces modified cells in sufficient numbers very rapidly at lower cost or these automated systems for cell and immunotherapies with similar production streamlining and potential cost reduction[1-5].

Outside of the field of medicine, a classic example of dropping prices is that of computers and electronics. At the beginning of the computer age, computers were huge pieces of machinery with very limited capabilities, and only few institutions in the world could afford having a few of them at best. However, as technology improved, the production of computers (and that of electronics in general) has become easier, cheaper, and more efficient, to the point that today we all walk around with tiny computers—smartphones—in our pockets, hundreds of times more powerful than those used by NASA to send the first people on the Moon.

Similarly, cars used to be too expensive for an average person to afford. Today, not only are cars ubiquitous and largely affordable, but even the newer, cutting-edge electric cars (for example, Tesla cars) are reaching the same price range as regular cars despite being relatively new on the market. Another example of the high-tech sector is that of 3D printers. A mere decade ago, a 3D printer cost around 100.000$; today, one can buy a good 3D printer for less than 500$—a price drop of 95.5%.

Even more interestingly this trend extends further to other areas of technology, for example the food industry. In 2013, the first lab-grown burger by FastCompany cost $325.000; a mere two years later, the cost had dropped to around $11. Even though FastCompany estimated it would take them two decades before they could turn the burger into a viable product, recently other companies have shown confidence that this can be achieved on a much shorter time scale.

For example, SuperMeat hope to have their first lab-grown meats available in stores in only five years, for the same price as regular meat or less. All the examples we have considered show that technology typically becomes much cheaper as time goes by; there is no reason to believe the same would not be true of rejuvenation technologies, especially when one takes into account an extremely strong economic motivator:

Rejuvenation would be the largest industry in history

The market for rejuvenation biotechnologies would be the largest in history and indeed some investors such as billionaire investment expert Jim Mellon, are already taking notice. Every single person in the world has aging and is thus a potential customer. It is of course very likely that those with wealth and therefore greater means will obtain cutting edge technology first (as we have seen repeatedly historically) before everyone else. This has always been the case and it has always been that shortly thereafter such technology and access becomes widespread.

However, one should consider that those early adopters are playing “guinea pig” and in effect are paving the way for the masses and helping developers offset the costs incurred during the development process due to paying premium prices for early access to these technologies.

 

Socio-economical considerations

If, for the sake of the argument, we assumed that rejuvenation biotechnologies could somehow be an exception to the trend of falling prices in technology, we would need to decide whether people ending up paying for their own rejuvenation therapies is more a realistic scenario than governments subsidising the treatments, partly or wholly.

The majority of countries in the world have universal healthcare systems that take care of their citizens or residents health needs either for free or for a nominal fee. These costs are offset by taxes which ensure the health service is able to provide this level of care to all.

Fig 2. 2009 Countries with universal Healthcare Source: Chartsbin

Other countries, in particular the US, do not have a universal healthcare system; citizens or residents of such countries generally have private health insurance to cover their medical expenses, and the coverage of each insurance plan may vary substantially, depending on what each individual subscriber can afford.

In many ways, aging can be considered to be a chronic, progressive, and fatal disease (indeed some researchers do[6]) of the type that insurance companies would likely not be willing to pay medical expenses for. However, we should take into account that its progression is remarkably slow. It generally takes decades for age-related diseases to manifest, so it would probably make little sense for anyone under forty years of age to include rejuvenation treatments in their health insurance. As a matter of fact, the very nature of the problem may call for an entirely different insurance strategy.

Presently, insurance policies are drawn up to cover the cost of potential risks that might lie ahead; this is the very reason why more likely risks make for more expensive policies and vice-versa. One is not guaranteed to get all age-related diseases—simply because one or few of them manage to kill us before we can get the others—but comprehensive, preventative rejuvenation necessarily needs to address all aspects of biological aging that may lead to any such ailments; in this sense, aging is a disease we all suffer from, and we will all suffer from each of the age-related diseases if we live long enough.

Therefore, aging is not a potential risk, but rather a certain fate that will strike each of us differently depending on individual circumstances. While the market share of each insurance company offering rejuvenation policies would be huge, such policies could not logically treat aging in the same way they treat potential risks. An insurance company will pay for a customer’s stolen car—or medical expenses for a certain disease—if and when the car has been stolen—or when the disease has struck.

However, aging is a lifelong process that needs to be addressed in a preventative fashion[7][8]; at no specific point could we say ‘aging has struck the patient now, but not before.’ This suggests private insurance may not be right way to go but instead, we should consider this matter from the point of view of the State.

Health costs in the current system are unsustainable

Presently, health expenditures for the elderly constitute a considerable burden on a country’s economy. Although the elderly have already contributed wealth to society when they were younger, they often stop doing so when they retire. Furthermore, they receive a pension from the State and will do so for the rest of their lives. While, in theory, pensions should already have been paid for by the elderly themselves with their work earlier in their lives, practice is quite different, and some countries are already increasing the retirement threshold further.

This is an unsustainable strategy, because barring radical interventions—such as rejuvenation therapies—there is a point past which elderly people simply are not healthy enough to work. As a matter of fact, the cost of medical expenses for the elderly grows dramatically each year, and it is also to be noted that geriatric treatments lead to no significant results, both in terms of overall individual well-being and fitness for work, and become increasingly less effective as the patients grow older. As a result, most individuals produce no wealth and their deteriorating health causes increasingly significant expenses during the last year or two of life and further strain on the economy[9].

The desired result of rejuvenation therapies leads to a much better scenario. If rejuvenation therapies are reapplied with proper timing, no individual would ever reach a state of age-related decay and poor health that could make him or her unfit for work. Consequently, the costs of treating age-related diseases using current medicine could be reduced with the arrival of more robust therapies offered by rejuvenation biotechnology. Such rejuvenation therapies aim to prevent a plethora of diseases before they manifest, potentially saving money. However, even if the costs are the same and we are simply trading one set of medicines for another, the benefit to health, quality of life and productivity makes it more than worth it regardless.

Retirement and increased lifespans

When considering retirement in relation to rejuvenation biotechnology, we should consider the two possible scenarios that may arise. The first scenario is the simple increase of lifespan beyond the current limits – this could be a few years or even a decade or two of healthy life. The Second scenario is that of negligible senescence, where medicine allows indefinite lifespans via periodic repair of the various damages and dysfunctions aging causes. Let’s take a look at both of these possibilities and consider the benefits and changes society may encounter as a result.

Scenario 1: Increased Lifespans. In a situation where additional healthy years were added to the human lifespan, an immediate benefit to society would be that people could retire later in life and continue to contribute economically and remain productive for longer. This would reduce the costs of pensions and help bolster the economy. Ultimately, in this scenario people would still retire as they already do, but later in life and with more healthy years to enjoy.

Scenario 2: Negligible senescence. In the more extreme case of negligible senescence, people would in principle be able to work indefinitely, regardless of their age, thus producing wealth nearly constantly. For this reason, retirement would likely change from a permanent cessation of working to the need for a break longer than a normal holiday, perhaps similar to a long-term work sabbatical. Pensions might even become optional, with workers taking these sabbatical breaks from work which could last some years and allow people to retrain and reinvent themselves.

Another remarkable benefit would be that the State would see drastically reduced costs traditionally spent on pensions as people would no longer retire in the traditional sense. It might be the case that the State would perhaps replace traditional pension schemes with sabbatical or UBI schemes to allow workers to accrue money over time to take such a break from work. If the State did not do this, then private enterprise might provide such a service.

In short, this second scenario has the potential to turn the current situation on its head—we would go from having high morbidity of age-related diseases that disable the elderly preventing them from being productive and causing major public expenses, to having productive elderly who contribute to the economy and whose health needs are little-to-no burden on it.

It’s easy to see how it would be far more convenient for any given State to pay for the periodical rejuvenation treatments of its citizens rather than maintaining the current state of affairs.

Apart from economical considerations, we must also keep in mind that, as said, rejuvenation therapies are life-saving medical treatments that prevent age-related diseases from ever manifesting. As such, ensuring their development and widespread access is among the objectives of WHO, according to its Constitution. The WHO Constitution says that each government is responsible for the health of its residents, and the attainment of the highest health standards is the very objective of WHO itself.

The WHO definition of ‘health’ is a ‘state of complete physical, mental and social well-being and not merely the absence of disease or infirmity’. Rejuvenation therapies match this definition perfectly: they would eliminate age-related diseases entirely and enable people to enjoy a normal life regardless of their age, without the limitations currently imposed on the elderly by their constantly declining health. They would improve the physical, mental, and social well-being of all people.

The WHO Constitution further states that ‘[t]he enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being without distinction of race, political belief, economic or social condition. In other words, because of the health standard improvements they would cause, rejuvenation therapies would be a basic right of everyone, and both local governments and WHO would have a responsibility to do all in their power to make sure this right is respected. (As a side note, this last paragraph of the Constitution would be better if it said that no distinction of age should be made either).

If not everyone can have it, then no one should have it?

Thus far, we’ve argued that while rejuvenation therapies may well be expensive at the beginning, they would be Stated-subsidised and would likely become cheaper and cheaper as the underlying technology improves. However, what if this prediction was wrong?

If everyone was supposed to pay for their own, expensive rejuvenation, then being indefinitely young would indeed be only for the rich, and the rich-poor gap would become even worse than it already is. It’s easy for people in developed countries to feel guilty about the privileges they have with respect to people in developing countries. Everlasting youth would be quite something to feel guilty about if not everyone had it. Not developing rejuvenation might thus prevent 1st-world people from having yet another thing to feel guilty about, but that’s all it would do – it would not help 3rd-world people in any way.

Let’s assume that we found out rejuvenation would be so expensive that only very rich people could afford it, and that for this reason we decided not to develop it at all. How would this affect the poor? We didn’t develop rejuvenation, so nobody got it, and in particular the poor didn’t. If we had developed rejuvenation, the poor wouldn’t have got it anyway, because it would have been to expensive for them to afford. So either way, nothing changed for the poor, and they certainly didn’t benefit from rejuvenation not existing.

What about the rich? If we didn’t develop rejuvenation for fear of increasing the gap between rich and poor, then the rich – like the poor – would keep getting sicker as they aged. Surely this didn’t make the gap larger, but it didn’t make it any narrower either. Not developing rejuvenation (or any other new technology, for that matter) doesn’t help the poor, and doesn’t close the rich-poor gap. If we think about it, we see that simply closing the gap isn’t enough. What really matters is how we close it. If developed countries gave up on all their comforts and wealth and became like the developing countries, then the gap would be closed, but no one would benefit from it. The only sensible way to close the rich-poor gap is making the poor better off, not the rich worse off.

Conclusion

So, no, not developing rejuvenation isn’t the way to go. Rejuvenation, like anything that can improve human life, needs to be developed. The concern rejuvenation might become a privilege of the rich only is legitimate, but the way to avoid this scenario is not to give up on rejuvenation entirely, but rather working hard to ensure it becomes as widespread and affordable as basic medicine. .

Each and everyone of us has the power to do something in this sense – be it by working on the necessary science, supporting it financially, lobbying to change relevant regulations, or even just spreading the word and let everyone know about this possibility. Our journey towards a future free from age-related diseases for everyone will be as short – or as long – as we will make it.

 

Literature

  1. Konagaya, S., Ando, T., Yamauchi, T., Suemori, H., & Iwata, H. (2015). Long-term maintenance of human induced pluripotent stem cells by automated cell culture system. Scientific reports, 5.
  2. Rafiq, Q. A., Twomey, K., Kulik, M., Leschke, C., O’Dea, J., Callens, S., … & Murphy, M. (2016). Developing an automated robotic factory for novel stem cell therapy production. Regenerative medicine, 11(4), 351-354.
  3. Chen, V. C., Ye, J., Shukla, P., Hua, G., Chen, D., Lin, Z., … & Hsu, D. (2015). Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells. Stem cell research, 15(2), 365-375.
  4. Conway, M. K., Gerger, M. J., Balay, E. E., O’Connell, R., Hanson, S., Daily, N. J., & Wakatsuki, T. (2015). Scalable 96-well plate based iPSC culture and production using a robotic liquid handling system. Journal of visualized experiments: JoVE, (99).
  5. Granzin, M., Soltenborn, S., Müller, S., Kollet, J., Berg, M., Cerwenka, A., … & Huppert, V. (2015). Fully automated expansion and activation of clinical-grade natural killer cells for adoptive immunotherapy. Cytotherapy, 17(5), 621-632.
  6. Bulterijs, S., Hull, R. S., Björk, V. C., & Roy, A. G. (2015). It is time to classify biological aging as a disease. Frontiers in genetics, 6.
  7. López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.
  8. Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., … & Rando, T. A. (2014). Aging: a common driver of chronic diseases and a target for novel interventions. Cell, 159(4), 709.
  9. Scitovsky, A. A. (2005). “The High Cost of Dying”: What Do the Data Show?. Milbank Quarterly, 83(4), 825-841.

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About the author

Nicola Bagalà

Nicola is a bit of a jack of all trades—a holder of an M.Sc. in mathematics; an amateur programmer; a hobbyist at novel writing, piano and art; and, of course, a passionate life extensionist. After his interest in the science of undoing aging arose in 2011, he gradually shifted from quiet supporter to active advocate in 2015, first launching his advocacy blog Rejuvenaction before eventually joining LEAF. These years in the field sparked an interest in molecular biology, which he actively studies. Other subjects he loves to discuss to no end are cosmology, artificial intelligence, and many others—far too many for a currently normal lifespan, which is one of the reasons he’s into life extension.
  1. January 30, 2018

    Very good article. We need to get people out of this “It’s only meant for the elite” mentality out of people’s heads. Once they realize it will be meant for everybody regardless of social status I think it will encourage people to put more effort in supporting it. The promise of a perpetual healthy life at peak health is too good to pass up.

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