We have been talking about a number of new studies in past Journal Clubs, so we thought it was time to get into some aging theory. We chose to cover one of the most cited and highly regarded damage theories of aging in this edition of the club.  In this edition of Journal Club we…

PCSK9 inhibitors, a new type of therapy, has arrived and appear to be an effective therapy for lowering LDL cholesterol to a level that exceeds the current standard of care. Recently, the results from a clinical trial at Brigham and Women’s Hospital showed that the drug evolocumab, when combined with statins, significantly and safely reduced…

The next Journal Club will be on Tuesday, September 26th at 13:00 EST/18:00 UK and will be streamed live from the Cooper Union, New York, to our Facebook page. We have been talking about a number of new studies in past Journal Clubs, so we thought it was time to get into some aging theory. We have chosen to…

If there was a poster child of aging diseases, it would be Alzheimer’s disease. The brains of people suffering from Alzheimer’s disease have deposits of amyloids resulting from the loss of proteostasis. Alzheimer’s disease is accompanied by the presence of amyloid beta protein and tau protein as well as large numbers of activated pro-inflammatory immune…

Coming from a fusion of the words ‘protein’ (a molecule that a cell uses as a machine or scaffolding) and ‘stasis’ (meaning to keep the same), the term ‘proteostasis’ can essentially be simplified into “Each function reliant on proteins is running as it should. There are enough proteins to serve a function, and the concentrations…

July 28th saw us run the third Journal Club, where we discussed a recent research publication. Journal Club is a monthly event livestreamed to our Facebook page and runs thanks to the support of our patrons – The Lifespan Heroes. Unfortunately, we had some technical issues with this stream and could not broadcast it live…

It is strange, really: we hear people talking about aging all the time, about the aches and pains, grey hairs and wrinkles, and yet few of us really understand the complex biology that is at work driving these processes. Let us explore what we know about aging so far thanks to science, but before we do,…

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