In April we talked about new Alzheimer’s research showing how a gene variant ApoE4 greatly increases the risk of developing the disease, and also how researchers have converted the defective gene back to its original form to cut the risk of the disease.

A new open access paper takes a look at the potential of regenerative medicine for the treatment of Alzheimer’s disease [1]. The review covers approaches such as spurring the production of new neurons and transplanting new neurons while taking a look at the disease-modeling approaches and techniques that science is now using to refine approaches…

Researchers at Gladstone Institutes in San Francisco report that a gene variant associated with Alzheimer’s works differently in mice and humans, and they also demonstrate how modifying this gene could potentially prevent the plaques associated with Alzheimer’s from forming and damaging the brain. The new study was published in the journal Nature in January 2018 [1]….

Dr. Oliver Medvedik will be hosting the next edition of Journal Club on Tuesday, April 19th at 13:00 EST. We will be discussing new research published in nature where researchers modified a protein associated with Alzheimer’s disease into a more harmless form, allowing them to remove the damage caused by Alzheimer’s in human cells. This…

New research from the University of Southern California has shed light on how the decline of the brain’s vascular system precedes the build-up of the plaques and tau tangles associated with Alzheimer’s disease. A leaky blood-brain barrier sets the scene for dementia Traditionally, many researchers have focused their efforts on the amyloid and tau proteins…

In the January Journal Club, we discussed the new drug J147 which targets mitochondrial dysfunction to potentially treat Alzheimer’s and other age-related diseases. We have also discussed the topic in an article last week if you wish to read about the progress being made with this drug. Reference Goldberg, J., Currais, A., Prior, M., Fischer, W., Chiruta, C., Ratliff,…

A simple technique to measure the amount of amyloid beta in the brain could improve diagnosis and drug trials for Alzheimer’s disease, according to the results of new research. A simple blood test Japanese researchers led by Dr. Katsuhiko Yanagisawa have published a new study suggesting that a screening test could help to boost the…

Researcher Dr. Dena Dubal, from the University of California San Francisco, is considering a new approach to combat neurodegenerative diseases, such as Alzheimer’s disease and dementia, using a protein known as klotho. Aging is the foundation of age-related diseases Instead of trying to understand each of these diseases and the complex mechanisms unique to both,…

In a paper in the Proceedings of the National Academy of Sciences, a research team led by Carlo Condello presented their results from a study of the sliced brain fragments of deceased Alzheimer’s disease (AD) patients. It appears different amyloid-beta prions are uniquely associated with different AD variants [1]. A primer on Alzheimer’s disease AD…

Journal Club will be held on our Facebook Page on, February 6th at 13:00 EST/18:00 UK. This was due to be held on January 30th but due to a problem at Cooper Union University where the stream is broadcast and presented from we have had to change the date. We will be discussing the new…

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