New research from the University of Southern California has shed light on how the decline of the brain’s vascular system precedes the build-up of the plaques and tau tangles associated with Alzheimer’s disease. A leaky blood-brain barrier sets the scene for dementia Traditionally, many researchers have focused their efforts on the amyloid and tau proteins…

In the January Journal Club, we discussed the new drug J147 which targets mitochondrial dysfunction to potentially treat Alzheimer’s and other age-related diseases. We have also discussed the topic in an article last week if you wish to read about the progress being made with this drug. Reference Goldberg, J., Currais, A., Prior, M., Fischer, W., Chiruta, C., Ratliff,…

A simple technique to measure the amount of amyloid beta in the brain could improve diagnosis and drug trials for Alzheimer’s disease, according to the results of new research. A simple blood test Japanese researchers led by Dr. Katsuhiko Yanagisawa have published a new study suggesting that a screening test could help to boost the…

Researcher Dr. Dena Dubal, from the University of California San Francisco, is considering a new approach to combat neurodegenerative diseases, such as Alzheimer’s disease and dementia, using a protein known as klotho. Aging is the foundation of age-related diseases Instead of trying to understand each of these diseases and the complex mechanisms unique to both,…

In a paper in the Proceedings of the National Academy of Sciences, a research team led by Carlo Condello presented their results from a study of the sliced brain fragments of deceased Alzheimer’s disease (AD) patients. It appears different amyloid-beta prions are uniquely associated with different AD variants [1]. A primer on Alzheimer’s disease AD…

Journal Club will be held on our Facebook Page on, February 6th at 13:00 EST/18:00 UK. This was due to be held on January 30th but due to a problem at Cooper Union University where the stream is broadcast and presented from we have had to change the date. We will be discussing the new…

J147 is an experimental drug that has been shown to treat Alzheimer’s disease, and it also appears to reverse some aspects of aging. It is also poised to enter human clinical trials in the near future, although how it works has been somewhat of a puzzle. A new study published in the journal Aging Cell…

Happy Holidays! Journal Club. Dr. Medvedik wanted to take a look at something a bit different this month. We are taking a look at a fascinating study where researchers used light to treat Alzheimer’s plaque formation in mice. This is considerably different to more traditional approaches to treat this disease so we thought we would…

Happy Holidays! Journal Club will be a bit earlier than usual this month as everyone will be busy celebrating the holidays soon. Dr. Medvedik wanted to take a look at something a bit different this month. We are taking a look at a fascinating study where researchers used light to treat Alzheimer’s plaque formation in…

Scientists at the École polytechnique fédérale de Lausanne (EPFL) have found a way to make mitochondria more resistant to damage, which could potentially be used to halt Alzheimer’s and other, similar, diseases. Globally, Alzheimer’s disease is the most common form of dementia and cause of neurodegeneration. It causes brain damage and symptoms such as long-term…

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