Today, as part of our series of articles that cover the Hallmarks of Aging, we are going to take a look at the role of proteins in cellular function and how they play a key role in aging. Proteins are essential for cellular function Proteins are large, complex molecules that regulate almost everything in your…

Researchers at Gladstone Institutes in San Francisco report that a gene variant associated with Alzheimer’s works differently in mice and humans, and they also demonstrate how modifying this gene could potentially prevent the plaques associated with Alzheimer’s from forming and damaging the brain. The new study was published in the journal Nature in January 2018 [1]….

PCSK9 inhibitors, a new type of therapy, has arrived and appear to be an effective therapy for lowering LDL cholesterol to a level that exceeds the current standard of care. Recently, the results from a clinical trial at Brigham and Women’s Hospital showed that the drug evolocumab, when combined with statins, significantly and safely reduced…

If there was a poster child of aging diseases, it would be Alzheimer’s disease. The brains of people suffering from Alzheimer’s disease have deposits of amyloids resulting from the loss of proteostasis. Alzheimer’s disease is accompanied by the presence of amyloid beta protein and tau protein as well as large numbers of activated pro-inflammatory immune…

Coming from a fusion of the words ‘protein’ (a molecule that a cell uses as a machine or scaffolding) and ‘stasis’ (meaning to keep the same), the term ‘proteostasis’ can essentially be simplified into “Each function reliant on proteins is running as it should. There are enough proteins to serve a function, and the concentrations…

We have been busy advocating for rejuvenation biotechnology. Elena Milova recently attended the first International Longevity and Cryopreservation Summit in Madrid with a talk about how to deliver the most effective messages to engage the general public to support aging and rejuvenation research. We will shortly have a number of exciting articles about the conference,…

The SENS Research Foundation (SRF) is a 501(c)(3) non-profit organization whose focus is on developing and ensuring widespread access to rejuvenation biotechnologies meant to bring the pathologies of old age under comprehensive medical control. SRF was co-founded in March 2009 by Michael Kope, Dr. Aubrey de Grey, Jeff Hall, Sarah Marr, and Kevin Perrott. The approach to…

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