Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline is the topic of this month’s Journal Club on October 30th at 1 pm ET. Abstract Cellular senescence, which is characterized by an irreversible cell-cycle arrest1 accompanied by a distinctive secretory phenotype2, can be induced through various intracellular and extracellular factors. Senescent cells that express…

Senolytics are the first therapies that directly target the aging process to delay or prevent age-related diseases and are now in human trials. Today we thought it was the ideal time to have a look at how they work and the companies involved. Senescent cells and aging As we get older, more and more of…

Oisin Biotechnologies is a rejuvenation biotechnology company that received its seed funding from the Methuselah Foundation and the SENS Research Foundation a few years ago. The current focus of Oisin is the targeted clearance of senescent cells through senolytics. Senescent cells are one of the hallmarks of aging, and as they accumulate, they encourage age-related…

We have been busy advocating for rejuvenation biotechnology. Elena Milova recently attended the first International Longevity and Cryopreservation Summit in Madrid with a talk about how to deliver the most effective messages to engage the general public to support aging and rejuvenation research. We will shortly have a number of exciting articles about the conference,…

The breaking news today is that yet another research group has entered the field of senescent cell clearance to treat aging. Therapies that remove senescent cells are known as senolytics, and they have been a hot topic for the past year or so. Before we talk about the new study, let’s take a look at…

The SENS Research Foundation (SRF) is a 501(c)(3) non-profit organization whose focus is on developing and ensuring widespread access to rejuvenation biotechnologies meant to bring the pathologies of old age under comprehensive medical control. SRF was co-founded in March 2009 by Michael Kope, Dr. Aubrey de Grey, Jeff Hall, Sarah Marr, and Kevin Perrott. The approach to…

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