A new study suggests that autophagy, the recycling, and disposal system that cells use to remove unwanted garbage, can extend the healthy lifespan of mammals. The study, led by Drs. Salwa Sebti and Alvaro Fernández from the Center for Autophagy Research, has discovered that mice with higher levels of autophagy live longer and healthier than…

Earlier this month, there was a human clinical trial of the supplement MitoQ, which showed some interesting results. We thought that we would take a look at the data, and discuss the findings. Literature [1] Rossman, M. J., Santos-Parker, J. R., Steward, C. A., Bispham, N. Z., Cuevas, L. M., Rosenberg, H. L., … &…

A substance found in aspirin has been demonstrated to replicate certain beneficial aspects of caloric restriction. Introduction Macroautophagy (hereafter referred to as autophagy) acts as a homeostatic pathway at both the cellular and organismal levels (Mizushima and Komatsu, 2011). The finely tuned execution of this multistep process (ensured by the coordinated activity of specifically committed Atg…

Researchers at Brown University have discovered a way to stimulate cellular autophagy, which is a natural recycling system built into every cell in the body. This has the potential to combat many age-related neurodegenerative diseases. What is autophagy? Autophagy means “eating of self” (from Ancient Greek “auto” = self, “phagein” = to devour). Autophagy is…

Scientists at the École polytechnique fédérale de Lausanne (EPFL) have found a way to make mitochondria more resistant to damage, which could potentially be used to halt Alzheimer’s and other, similar, diseases. Globally, Alzheimer’s disease is the most common form of dementia and cause of neurodegeneration. It causes brain damage and symptoms such as long-term…

Autophagy means “eating of self” (from Ancient Greek “autó”= self;  and “phagein” = to devour)[1]. Although its name might sound harmful, autophagy appears to have longevity-promoting effects[2]. Here we will explain what autophagy is, how it works, its benefits, and how it plays a role in aging. What is Autophagy? Autophagy is the way cells…

Today, we decided that it was a good time to take a look at a new study that demonstrates that increasing autophagy is a good approach to slowing aging and could be the foundation for a variety of therapies to treat age-related diseases. What is Autophagy? Autophagy is an intracellular degradation system that delivers unwanted…

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