Today, we want to discuss this review published in the journal Science, as it provides a whistle-stop tour of caloric restriction, intermittent fasting, and time-restricted feeding. There is a considerable amount of data supporting the effects of caloric restriction and similar dietary approaches on both health and lifespan in multiple species. In general, the more…

Researchers from the Kapahi Lab at the Buck Institute for Research on Aging have shown in a new study that increased intestinal permeability is caused by the age-related loss of epithelial cells that form the gut membrane [1]. As we age, the integrity of the gut membrane declines, and it becomes more permeable; this is…

Hypertension is an increasingly encountered condition in modern society, as sedentary lifestyles, poor diet, and other unhealthy lifestyle choices are becoming more prevalent. The aging processes generally cause our blood pressure to rise, as they steadily clog our arteries, stiffen blood vessels, and cause our hearts to work harder to get blood to all our…

A substance found in aspirin has been demonstrated to replicate certain beneficial aspects of caloric restriction. Introduction Macroautophagy (hereafter referred to as autophagy) acts as a homeostatic pathway at both the cellular and organismal levels (Mizushima and Komatsu, 2011). The finely tuned execution of this multistep process (ensured by the coordinated activity of specifically committed Atg…

Could caloric restriction be the most reliable health and longevity approach that we have available right now while we wait for medical technology to progress? A new review suggests that “calorie restriction is the most reasonable anti-ageing intervention”. Is this the best we can do for now? A new meta-analysis of caloric restriction studies has…

Caloric restriction has long been known to increase the lifespan and healthspan of most studied animals. Research also shows that animals given a calorie-restricted diet are also generally more able to regenerate tissue damage following injury. Caloric restriction improves tissue regeneration A new study by the Lengner lab at the University of Pennsylvania has identified…

Periodic fasting has long been demonstrated to have beneficial effects on autoimmune disorders, cancer prevention and treatments, cardiovascular disease, and a myriad of other ailments. This most recent paper by Cheng et al. might add the treatment of Type 1 diabetes to that list[1]. If successful in humans, it has the potential to reverse some or most of…

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