Researchers from the Walter and Eliza Hall Institute, the Monash Institute of Pharmaceutical Sciences, and Cancer Therapeutics CRC have developed a new type of drug that harnesses cellular senescence as a weapon against cancer [1]. Study abstract Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function. Among the genes coding…

Researchers at the Rockefeller University have clarified the mechanism by which certain types of breast cancer become immune to specific drugs designed to eliminate them. More specifically, they figured out how the loss of the protein 53BP1 due to BRCA1 mutation allows cancers to become insensitive to PARP inhibitors [1]. Study summary In DNA repair,…

Two papers authored by researchers at the University of California, San Francisco described the genetic changes that turn harmless moles into malignant melanomas and the experiment they devised to recreate the step-by-step evolution of normal skin cells into cancer cells [1], [2]. Summary ([1]) We elucidated genomic and transcriptomic changes that accompany the evolution of…

According to a new study published in the journal Cell Metabolism, it might be possible to attack cancer by exploiting its own cellular metabolism rather than by employing drugs to kill cancerous cells directly [1]. Study summary Although breast cancer stem cells (BCSCs) display plasticity transitioning between quiescent mesenchymal-like (M) and proliferative epithelial-like (E) states,…

Researchers have manipulated the immune system to respond more aggressively to cancer according to a new study [1]. Manipulating macrophages We have discussed modulating the immune system multiple times recently, especially in regards to macrophages and manipulating their behavior. Macrophages are part of the innate immune system and carry out a wide variety of tasks,…

A team at the Institute of Cancer Research in London led by Dr. Barbara Tanos has found out that cellular organelles known as “cilia” may be a viable target for undermining many cancers’ drug resistance [1]. Study summary Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of…

Researchers from the National Cancer Institute (NCI), the University of Kansas, and the National Center for Advancing Translational Science (NCATS) have discovered a compound that can block the spread of some types of cancer cells. Preventing cancer metastasis Metastasis is how cancer spreads from an initial site to a secondary site within the host’s body;…

Korean and Singaporean scientists have recently proposed a new probe to detect cancer stem cells, and it might be an effective seek-and-destroy weapon against a variety of cancer types. In a paper published in the journal Angewandte Chemie earlier this month, the researchers describe a fluorescent dye that they created to highlight cancer stem cells,…

New research has identified the mechanisms responsible for enhancing immune system activity, offering new approaches for more effective cancer treatments and vaccines. Invariant natural killer T (iNKT) cells are part of the immune system’s arsenal for fighting infection and defeating diseases like cancer. Finding ways to activate these potent cells more quickly could lead to…

Researchers have identified a protein that is different between healthy and cancerous cells, offering a potential target for therapeutic interventions. Abstract Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation…

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