A team at the Institute of Cancer Research in London led by Dr. Barbara Tanos has found out that cellular organelles known as “cilia” may be a viable target for undermining many cancers’ drug resistance [1]. Study summary Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of…

Researchers from the National Cancer Institute (NCI), the University of Kansas, and the National Center for Advancing Translational Science (NCATS) have discovered a compound that can block the spread of some types of cancer cells. Preventing cancer metastasis Metastasis is how cancer spreads from an initial site to a secondary site within the host’s body;…

Korean and Singaporean scientists have recently proposed a new probe to detect cancer stem cells, and it might be an effective seek-and-destroy weapon against a variety of cancer types. In a paper published in the journal Angewandte Chemie earlier this month, the researchers describe a fluorescent dye that they created to highlight cancer stem cells,…

New research has identified the mechanisms responsible for enhancing immune system activity, offering new approaches for more effective cancer treatments and vaccines. Invariant natural killer T (iNKT) cells are part of the immune system’s arsenal for fighting infection and defeating diseases like cancer. Finding ways to activate these potent cells more quickly could lead to…

Researchers have identified a protein that is different between healthy and cancerous cells, offering a potential target for therapeutic interventions. Abstract Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation…

Researchers at Harvard have described a new cancer vaccine approach that uses an injectable biomaterial scaffold to deliver a payload of tumor-specific peptides that stimulate the immune system to respond rapidly to cancer cells. Abstract Existing strategies to enhance peptide immunogenicity for cancer vaccination generally require direct peptide alteration, which, beyond practical issues, may impact…

Some cancer cells express some of the same genes that senescent cells do, so it makes sense that drugs that destroy senescent cells may also destroy cancer cells. This was what the researchers in this new study set out to test. Abstract p16Ink4a is a potent cell cycle inhibitor engaged to support cell cycle arrest…

In a new study, researchers at the Johns Hopkins Kimmel Cancer Center have shown that the epigenetic alterations associated with cancer evolve in an erratic manner during the early stages of tumor formation [1]. These tumor-associated epigenetic changes ultimately focus on a subset of genes that are also observed in aging. Cancer and senescent cells…

Researchers have created tiny DNA nanorobots that can deliver a protein payload that cuts off the blood supply to tumors in mice. DNA Origami According to a new study, the research team was able to create DNA nanorobots that can travel through the bloodstream, locate tumors, and deliver a protein that induces blood clotting, thus…

Last year, we talked about a new cancer “vaccine” currently in clinical trials in an article here, and now a second cancer vaccine is capturing media interest due to impressive results in the lab. The new therapy is now in human clinical trials for lymphoma patients. Researchers at Stanford Medicine have found that injecting two…

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