The topic for the September Edition of the Journal Club was the recent human trial of senolytic agents Dastatinib and Quercetin. For the researchers at the Mayo Clinic this was a follow on study from their previous human trial targeting IPF. This time the researchers ran a study to see how senolytics influenced diabetic kidney…

Researchers at the Buck Institute, including Dr. Judy Campisi, have published a new study that shows, for the first time, that senescent cells are associated with age-related blood clots [1]. As we get older, increasing numbers of our cells enter into a state known as cellular senescence. Senescent cells do not divide or support the…

Researchers have launched a new database dedicated to mapping and understanding the complexity of cellular senescence in a bid to help us fully understand this age-related phenomenon.  Introducing the CellAge database The Human Ageing Genomic Resources (HAGR) is a series of databases and tools that have been developed to aid researchers on aging and help…

A new publication highlights how the complex interaction of NAD+ and cellular senescence pathways may complicate proposed anti-aging therapies that boost NAD+ using precursors. What are epigenetic alterations? One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations….

Aging is a series of processes in which the body’s ability to perform functions gradually decreases. The Hallmarks of Aging includes such things as an increase in senescent cells and a decrease in stem cells, but decreasing NAD+ and increasing free radicals matter as well. This article will cover a few root causes of aging…

A small update from the MMTP project team following meeting the lead investigator Dr. Alexandra Stolzing in Berlin recently. Hi everyone, it has been a while and as we have recently spoken to Dr. Alexandra Stolzing at the Undoing Aging conference in Berlin about the MMTP we wanted to give a small update. Dr. Stolzing…

Last month, researchers at Johan Auwerx’s lab at the Ecole Polytechnique Fédérale de Lausanne (EPFL) had looked at the connections between RNA-binding proteins and aging. RNA binding proteins (RBPs) play an important part in post-transcriptional control by binding to mRNA. After binding, RBPs can aid in the processing of pre-mRNA as well as mRNA stability,…

For the January Journal Club, we will be taking a look at the recent human senolytics trial conducted at the Mayo Clinic. Abstract Background Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively…

The results from a human pilot study that focused on treating idiopathic pulmonary fibrosis with senescent cell-clearing drugs has been published. The drugs target aged and damaged cells, which are thought to be a reason we age and get sick, and remove them from the body. Senescent cells and aging As we age, increasing numbers…

There has been considerable interest in fisetin recently, especially for its potential as a senolytic, which clears away dysfunctional senescent cells that accumulate with aging. Researchers believe that fisetin may be useful in increasing the healthy period of life known as healthspan. What is Fisetin? Fisetin is a naturally occurring flavonol and part of the…

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