Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline is the topic of this month’s Journal Club on October 30th at 1 pm ET. Abstract Cellular senescence, which is characterized by an irreversible cell-cycle arrest1 accompanied by a distinctive secretory phenotype2, can be induced through various intracellular and extracellular factors. Senescent cells that express…

Senolytics are the first therapies that directly target the aging process to delay or prevent age-related diseases and are now in human trials. Today we thought it was the ideal time to have a look at how they work and the companies involved. Senescent cells and aging As we get older, more and more of…

Scientists from the A*STAR Singapore Immunology Network have discovered that immune cells called nonclassical monocytes undergo cellular senescence, contradicting what was previously thought of them [1]. Abstract Human primary monocytes comprise a heterogeneous population that can be classified into three subsets based on CD14 and CD16 expression: classical (CD14high/CD16−), intermediate (CD14high/CD16+), and non-classical (CD14low/CD16+). The…

Today, we want to bring your attention to a recent mouse study on fisetin, a commonly available supplement that has proven effective at destroying senescent cells. What are senescent cells? As we age, increasing amounts of our cells enter into a state known as senescence. Normally, these cells destroy themselves by a self-destruct process known…

Today, we have an update from the MMTP Project team. The project was launched on Lifespan.io back in 2016 with the aim of testing senolytics and their effect on lifespan, it was successfully funded and raised 15% over its initial goal. Hi everyone, it has been a long time so we thought it was time…

Today, we would like to share a talk given by Stephen Hilbert, President of Oisin Biotechnologies, in which he discusses treating aging and cancer by removing harmful senescent cells. On July 12th, we hosted our first conference, Ending Age-Related Diseases: Investment Prospects & Advances in Research, at the Frederick P. Rose Auditorium, which is part…

According to a study by Georgia State University scientists, a molecule called β-hydroxybutyrate has anti-aging effects on the vascular system; more specifically, the molecule appears to prevent senescence of vascular cells by promoting cellular quiescence instead [1]. Study abstract β-hydroxybutyrate (β-HB) elevation during fasting or caloric restriction is believed to induce anti-aging effects and alleviate…

Today we have a small update from the Cellage team. The Cellage project is aiming to use synthetic biology to create a new way to detect the presence of harmful senescent cells as current methods are less than ideal and not as accurate as we need. Hi there, We have been quiet for a while…

Today, we want to point out a new publication that dives into the world of senolytics, which are drugs or therapies that seek and destroy harmful non-dividing cells that resist the programmed cell death known as apoptosis. These cells linger in the body, and, as we age, more and more of them accumulate and contribute…

Today, we wanted to draw your attention to a recent study showing an association between the accumulation of Tau proteins, which are misfolded proteins that typically indicate Alzheimer’s disease and senescent cells. The researchers also showed that Tau pathology was improved by the use of drugs that remove non-dividing senescent cells. Unfortunately, this journal paper…

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