During the Fourth Eurosymposium on Healthy Ageing (EHA), which was held in Brussels, Belgium last November, we had the opportunity to meet Dr. Daniel Muñoz-Espín from the Oncology Department of the University of Cambridge. Dr. Muñoz-Espín received his PhD from the Autonomous University of Madrid, Spain, within the viral DNA replication group at the Centre…

The topic for the December Journal Club was the recently published paper Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement, a plant-based polyphenol, appears to influence aging in mice by clearing senescent cells, which are one of the hallmarks of aging. There is certainly plenty of justification for moving this compound…

The topic for the December Journal Club will be the recently published paper – Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement and a plant-based polyphenol appears to influence the aging process in mice by clearing senescent cells, one of the suggested reasons we age. There is certainly plenty of justification…

A number of therapies that directly target the aging processes are currently in human trials and could change medicine significantly in the next decade if the results are positive. What is aging? Aging is basically the accumulation of damage and errors caused by a collection of varied processes that harm the functions of the body…

Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. Dr. Oliver Medvedik, Steve Hill, and Victor Bjoerk discussed this interesting study…

Today, we want to point out a new study showing how senescent cells poison their healthy neighbors and that the more there are, the faster they make other cells become senescent. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide…

Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. We will see you live on our Facebook page at 13:00 EST for…

At the Eurosymposium on Healthy Ageing, we had the privilege of interviewing Dr. Marco Demaria of the European Research Institute for the Biology of Ageing. In this interview with Elena Milova, Dr. Demaria primarily talks about senescent cells, their role in age-related diseases, and methods of controlling them. Among the ways of controlling them include…

We wanted to bring your attention to a recent publication that discusses the topic of cellular senescence and the contributions of senescent cells to aging and disease [1]. What is perhaps the most interesting part of this paper is the section covering the potential future directions that researchers may take in managing senescent cell populations…

The October Journal Club will be focusing on a new study in worms where a combination of compounds acted in synergy to almost double lifespan. SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We…

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