Today, we want to draw attention to a new study that shows how partial cellular reprogramming was able to reverse cellular aging and address age- and injury-induced blindness in mice. Epigenetic alterations One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are…

Researchers have tested nicotinamide mononucleotide on aged mice to see if it can help reverse age-related cognitive decline by improving blood flow in the brain. The brain is a hungry organ Healthy brain function relies on efficient cerebral blood flow (CBF) to wash away harmful waste products for disposal and supply the brain with an…

Just a small update for those who backed the recent NAD+ Mouse Project on Lifespan.io: the T-shirt rewards for backers are now shipping. We anticipate that 90% of shipments will be sent out by today and that most U.S. backers should have them by Friday, December 21 and almost all will have them by Saturday,…

Yesterday, we announced the successful completion of the NAD+ Mouse Project after a great fundraiser, but it seems we are not done yet. The research team at Harvard has announced a new stretch goal for the last two days of the campaign. A new $75,000 goal is to be the final step, and to support…

Great news! The NAD+ Mouse Project has passed its second fundraising stretch goal, which means that the experiment will greatly expand its scope. The research team will now have enough funding to buy enough NMN to conduct long-term studies on its effects on health and the aging processes. The project will monitor the mice for…

On the 23rd of this month, Dr. David Sinclair did an Ask Me Anything over at the Futurology subreddit in support of the NAD+ Mouse Project on Lifespan.io. There were a range of interesting questions from the community about his work in aging research, particularly the role of NAD+ in aging. Dr. David A. Sinclair…

Today, we are delighted to announce that there is to be a third funding match for the NAD+ Mouse Project! Dr. David Sinclair will be personally matching the next $5000 in donations for the last 10 days of the campaign to help reach the final $60,000 goal. Now, that is what we call a devoted…

In support of the NAD+ Mouse Project over at Lifespan.io, Dr. David Sinclair will be doing an AMA on Reddit Futurology Tuesday, October 23, 2018 from 11:00 – 12:00 AM EDT. Dr. Sinclair will be answering questions from the community about his work with NAD+ biology, Sirtuins, and why the NAD+ Mouse Project is important…

We have wonderful news today: the NAD+ Mouse Project has reached the first stretch goal of $45k! This greatly expands the scope of the experiment, which will now include a long-term study of the effects of NMN on aging in regular and ICE mice. Attaining our first stretch goal will enable us to perform longer…

Senolytics are the first therapies that directly target an aging process in order to delay or prevent age-related diseases, and they are now in human trials. Today, we think that it is the ideal time to have a look at how they work and what companies are involved. Senescent cells and aging As we get…

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