The Journal club returned for a Halloween special and Dr. Oliver Medvedik looked at a recent paper which showed a combination of three drugs had a synergistic effect and increased lifespan greatly in fruit flies. The drugs all target parts of the nutrient sensing system which controls metabolism and its deregulation is proposed to be…

The Journal club returns for a Halloween special and this time around, Dr. Oliver Medvedik is taking an in depth look at a recent paper which showed a combination of three drugs had a synergistic effect and increased lifespan greatly in fruit flies. The drugs all target parts of the nutrient sensing system which controls…

Today, we want to spotlight a recent study showing that boosting nicotinamide adenine dinucleotide (NAD+) levels in mice prevents age-related hearing loss. What is β-Lapachone? β-Lapachone is a quinone-containing compound that was originally isolated from the lapacho tree in South America. It is worth noting that this tree has been used as a herbal medicine…

Researchers have discovered a new drug that targets the mTOR pathway, which is involved in aging and metabolism. It could function as a caloric restriction mimetic, bringing about similar health benefits. The mTOR pathway The mechanistic target of rapamycin (mTOR) pathway is a part of metabolism and is one of the four major pathways that…

Today, we want to highlight a new publication that looks at cytomegalovirus (CMV) and its potential role in the development of metabolic syndrome. What is cytomegalovirus?  CMV is part of the β-subfamily of herpes viruses, a family of viruses that are believed to have been co-evolving with their hosts for around 180 million years [1]….

Last year, resTORbio announced the positive results of its phase 2b human trial, which targeted the aging immune system with an immune system-boosting drug. Now, the company has announced the news that its therapy is moving to a phase 3 study later this year after successful negotiation with the FDA. Targeting the mTOR pathway of…

A new study published in Nature Metabolism finally reveals the answer to how NMN enters the cell in order to become NAD+ and that it does not need to convert into NR to do so. In the last few years, there has been considerable interest in restoring levels of the nicotinamide adenine dinucleotide (NAD+) coenzyme…

A new study takes a look at the relationship between metabolism, aging, and type 2 diabetes and in particular the mTORC1 protein complex, part of the mTOR pathway. The mTOR pathway The mechanistic target of rapamycin (mTOR) pathway is a major part of metabolism and is one of four major pathways that control it; collectively,…

Today, we want to highlight a new study that used in silico analysis to look at the interaction between metformin and SIRT1 [1]. SIRT1 and metabolism Silent mating type information regulation 2 homolog (SIRT1) is a member of the sirtuin protein family, and studies suggest that human sirtuins act as intracellular regulatory proteins. Sirtuin 1…

Today, we are pleased to announce that the results are in from a human trial that targets the aging immune system and that an immune system-boosting drug appears to be effective. Targeting TORC1 to boost the immune system As we age, the immune system becomes increasingly poor and unable to detect and fight infections. This…

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