A team of researchers, including renowned geneticist Professor George Church, has published a new paper demonstrating the mitigation of multiple age-related diseases using a multi-target gene therapy. Treating multiple age-related diseases at once George Church is a very prominent figure in genetics and aging research, and he created quite a stir last year when he…

Scientists have shown that the removal of non-dividing senescent cells, which are normally associated with aging, also appears to prevent Type 1 diabetes in diabetic mouse strains. Clearing senescent beta cells prevents T1 diabetes Type 1 diabetes (T1D) is a chronic condition in which the pancreas produces little or no insulin. Insulin is a hormone…

Welcome to part two of a two-part series exploring NAD+ biology; you can find part one here. There are already a myriad of excellent reviews on NAD+ biology in general [1-3], so, in this article, we will be mainly focusing on the NAD+ precursor nicotinamide mononucleotide (NMN). NMN and synthesis of NAD+ NMN can be…

Progress has been made towards a potential solution to type 1 diabetes. The novel approach seeks to cure type 1 diabetes and to allow type 2 diabetics to stop using insulin shots by altering other cells in the pancreas so they produce insulin. The research team based at UT Health San Antonio have found a…

Alpha-lipoic acid is a common supplement, but what about its geroprotective properties? We take a look at this supplement in another of our geroprotector articles. History Alpha-lipoic acid (ALA) was first discovered in 1937, when Snell discovered that a type of bacteria relied on potato juice to reproduce[1]. This led to alpha-lipoic acid being known…

Periodic fasting has long been demonstrated to have beneficial effects on autoimmune disorders, cancer prevention and treatments, cardiovascular disease, and a myriad of other ailments. This most recent paper by Cheng et al. might add the treatment of Type 1 diabetes to that list[1]. If successful in humans, it has the potential to reverse some or most of…

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